63416-70-6

Basic information

• Product Name: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE;3-(4-Fluorophenyl)propanal;Benzenepropanal, 4-fluoro-;3-(4-flurophenyl)propionaldehyde
• CAS NO: 63416-70-6
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• Mol File: 63416-70-6.mol
• Article Data: 59

Chemical Properties

• Boiling Point: 208.695°C at 760 mmHg
• Flash Point: 85.096°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 0.211mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(63416-70-6)
• EPA Substance Registry System: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(63416-70-6)

Safety Data

• Hazardous Substances Data: 63416-70-6(Hazardous Substances Data)

Usage

General Description

3-(4-Fluoro-phenyl)-propionaldehyde is a chemical compound with the molecular formula C9H9FO. It is a colorless to pale yellow liquid with a sweet, floral odor. This aldehyde is commonly used as a flavoring agent in the food and beverage industry, adding a pleasant floral or fruity note to various products. Additionally, it has applications in the fragrance industry, where it is used to create perfumes and other scented products. It is important to handle this chemical with care, as it can irritate the skin, eyes, and respiratory system and should be stored and used in a well-ventilated area.

InChI:InChI=1/C9H9FO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-7H,1-2H2

Upstream product

• 7116-38-3 ethyl 3-(4-fluorophenyl)propanoate 
• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 459-57-4 4-fluorobenzaldehyde 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 405-99-2 para-fluorostyrene 
• 201230-82-2 carbon monoxide 
• 124980-95-6 3-(4-fluorophenyl)prop-2-en-1-ol 
• 64-18-6 formic acid 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 2928-14-5 3-(4-Fluorophenyl)propionic acid,methyl ester 
• 51791-26-5 3-(4-fluoro-phenyl)-propenal 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 123-63-7 paracetaldehyde 

Downstream Products

• 1440430-82-9 (2'S,4'R,6'S)-2'-(4'''-fluorophenethyl)-6'-(4''''-hydroxy-3''''-methoxyphenyl)tetrahydropyran-4'-yl acetate 
• 1440431-99-1 (2S,4R,6S)-2-(4''-fluorophenethyl)-6-(4'''-hydroxy-3'''-methoxyphenyl)tetrahydropyran-4-yl-3''''-(4'''''-methoxyphenyl)propyl carbonate 
• 1440432-16-5 (2S,4R,6S)-2-(4''-fluorophenethyl)-6-(3'''-bromo-4'''-hydroxy-5'''-methoxyphenyl)tetrahydropyran-4-yl-3''''-(4'''''-methoxyphenyl)propyl carbonate 
• 1440430-69-2 (2'S,4'R,6'S)-2'-(4'''-fluorophenethyl)-6'-(4''''-hydroxyphenyl)tetrahydropyran-4'-yl acetate 
• 1440431-32-2 (2S,4R,6S)-2-(4''-fluorophenethyl)-6-(4'''-hydroxyphenyl)tetrahydropyran-4-ol 
• 1440431-36-6 (2S,4R,6S)-2-(4''-fluorophenethyl)-6-(4'''-hydroxy-3'''-methoxyphenyl)tetrahydropyran-4-ol 
• 1440431-48-0 (2S,4R,6S)-2-(4''-fluorophenethyl)-6-(3'''-bromo-4'''-hydroxy-5'''-methoxyphenyl)tetrahydropyran-4-ol 
• 1440432-75-6 (S)-1-(4'-fluorophenyl)hex-5-ene-3-ol 
• 852661-39-3 N-({(1S,2R)-2-[[3-(4-fluorophenyl)propyl](methyl)amino]cyclohexyl}methyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea 

Relevant articles and documents

Ligand-controlled cobalt-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes

The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.

Multicatalytic approach to one-pot stereoselective synthesis of secondary benzylic alcohols

One-pot procedures bear the potential to rapidly build up molecular complexity without isolation and purification of consecutive intermediates. Here, we report multicatalytic protocols that convert alkenes, unsaturated aliphatic alcohols, and aryl boronic acids into secondary benzylic alcohols with high stereoselectivities (typically >95:5 er) under sequential catalysis that integrates alkene cross-metathesis, isomerization, and nucleophilic addition. Prochiral allylic alcohols can be converted to any stereoisomer of the product with high stereoselectivity (>98:2 er, >20:1 dr).

Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts

Here, the streptavidin-biotin technology was applied to enable organocatalytic transfer hydrogenation. By introducing a biotin-tethered pyrrolidine (1) to the tetrameric streptavidin (T-Sav), the resulting hybrid catalyst was able to mediate hydride transfer from dihydro-benzylnicotinamide (BNAH) to α,β-unsaturated aldehydes. Hydrogenation of cinnamaldehyde and some of its aryl-substituted analogues was found to be nearly quantitative. Kinetic measurements revealed that the T-Sav:1 assembly possesses enzyme-like behavior, whereas isotope effect analysis, performed by QM/MM simulations, illustrated that the step of hydride transfer is at least partially rate-limiting. These results have proven the concept thatT-Savcan be used to host secondary amine-catalyzed transfer hydrogenations.