63536-46-9

Basic information

• Product Name: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• CAS NO: 63536-46-9
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Product Categories: QUINOLINONE
• Mol File: 63536-46-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 64-65 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 309.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: -0.39±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)

Safety Data

• Hazardous Substances Data: 63536-46-9(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a quinoxalinone ring with an ethyl substituent

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Usage

Building block in the production of other chemical compounds (e.g. pesticides and dyes)

Potential

Biological activities

Applications

Medicinal chemistry and drug discovery

Note

Specific properties and uses may vary depending on the context and the specific research or industrial application.

Upstream product

• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 64-17-5 ethanol 
• 74-96-4 ethyl bromide 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 
• 75-03-6 ethyl iodide 
• 1196-57-2 2-hydroxyquinoxaline 
• 59564-59-9 1,2,3,4-tetrahydroquinoxalin-2-one 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 95-54-5 1,2-diamino-benzene 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 75-00-3 chloroethane 

Downstream Products

• 73148-14-8 1-ethyl-3-methylquinoxalin-2(1H)-one 
• 1186527-86-5 3-(4-chlorophenyl)-1-ethylquinoxalin-2(1H)-one 
• 88392-55-6 1-ethyl-3-phenylquinoxalin-2(1H)-one 

Relevant articles and documents

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis

Herein, a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated. A wide range of functional groups are compatible, affording the corresponding products in moderate-to-good yields. Control experiments illustrate that the in situ generated 1O2 plays a central role in this reaction. This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure.

Metal-Free Direct Oxidative C?N Bond Coupling of Quinoxalin-2(1H)-ones with Azoles under Mild Conditions

Direct C3?H amination of quinoxalin-2(1H)-ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram-scale reaction.