637-32-1 Usage
Description
Proguanil Hydrochloride, also known as Chlorguanide, is a synthetic compound that serves as an antimalarial drug. It is a derivative of biguanide and has a unique chemical structure that allows it to be effective against the Plasmodium parasite, which causes malaria. Proguanil Hydrochloride is characterized by its ability to inhibit the dihydrofolate reductase enzyme, which is essential for the parasite's survival and reproduction.
Uses
Used in Pharmaceutical Industry:
Proguanil Hydrochloride is used as an antimalarial drug for the prevention and treatment of malaria caused by Plasmodium falciparum and other Plasmodium species. It is effective in both prophylactic and therapeutic applications, making it a valuable tool in combating malaria in endemic regions.
Used in Research and Development:
Proguanil Hydrochloride is used as an internal standard for the quantification of Proguanil by GCor LC-mass spectrometry. This application is crucial in ensuring the accurate measurement and quality control of the drug in various formulations and dosages.
Used in Drug Development:
Proguanil Hydrochloride is used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy, and methods of delivery. This research is essential in understanding the drug's behavior in the body and optimizing its use as an antimalarial agent.
Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
Check Digit Verification of cas no
The CAS Registry Mumber 637-32-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 637-32:
(5*6)+(4*3)+(3*7)+(2*3)+(1*2)=71
71 % 10 = 1
So 637-32-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
637-32-1Relevant articles and documents
BIGUANIDE COMPOUND AND USE THEREOF
-
Paragraph 0032; 0033; 0064; 0065, (2017/10/07)
The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.
