64-55-1 Usage
Originator
Capla,Wallace,US,1961
Uses
Antihypertensive.
Manufacturing Process
The following example illustrates the preparation of 2-methyl-2-sec-butyl-1,3- propanediol: 92 g of diethyl-sec-butyl methyl malonate were reduced in the usual manner using 22.8 g of lithium aluminum hydride in a suitable volume of anhydrous ethyl ether. The mixture was treated with 10% sulfuric acid and the ether soluble components extracted. The ether solution was dried, using a suitable drying agent, and the residue obtained by the removal of the ether was purified by distilling under reduced pressure. This material was further purified by redistillation. Approximately 46 g of 2-methyl-2-sec-butyl-1,3-propanediol were obtained as a clear colorless liquid, boiling point 92°C to 97°C (0.1 mm pressure). The following example describes the preparation of 2-methyl-2-sec-butyl-1,3- propanediol dicarbamate using the urethane exchange method: 14.6 g of 2-methyl-2-sec-butyl-1,3-propanediol and 18.7 g ethyl urethane are dissolved in about 100 ml anhydrous toluene. 3 g of aluminum isopropylate are added and the mixture distilled to remove the ethyl alcohol formed in the condensation of ethyl urethane and the diol. The alcohol distills in the form of an azeotrope with toluene. Distillation is continued until the theoretical quantity of ethanol has been removed. The toluene is distilled from the mixture under reduced pressure and the residue dissolved in hot aqueous isopropanol solution. The hot solution is filtered and allowed to cool, whereupon approximately 14 g of product separates. The purified product represents a yield of about 60% of theoretical and melts at 77°C to 79°C.
Brand name
Dormate (Medpointe).
Therapeutic Function
Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 64-55-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64-55:
(4*6)+(3*4)+(2*5)+(1*5)=51
51 % 10 = 1
So 64-55-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2O4/c1-4-7(2)10(3,5-15-8(11)13)6-16-9(12)14/h7H,4-6H2,1-3H3,(H2,11,13)(H2,12,14)
64-55-1Relevant articles and documents
Method for the preparation of 2,3-dimethyl-pent-4en-aldehyde
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, (2008/06/13)
A process for the production of 2-methyl-2-sec. butyl-1,3-propanediol from crotyl alcohol is disclosed. The diol obtained is useful in the manufacture of 2-methyl-2-(1-methylpropyl)-1,3-propanediol dicarbamate a valuable antihypertensive agent.
