64131-74-4

Basic information

• Product Name: Quinoline, 2-[2-(2-nitrophenyl)ethenyl]-, (E)-
• CAS NO: 64131-74-4
• Molecular Formula: C17H12N2O2
• Molecular Weight: 276.294
• Mol File: 64131-74-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Quinoline, 2-[2-(2-nitrophenyl)ethenyl]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 2-[2-(2-nitrophenyl)ethenyl]-, (E)-(64131-74-4)
• EPA Substance Registry System: Quinoline, 2-[2-(2-nitrophenyl)ethenyl]-, (E)-(64131-74-4)

Safety Data

• Hazardous Substances Data: 64131-74-4(Hazardous Substances Data)

Upstream product

• 91-63-4 2-methylquinoline 
• 552-89-6 2-nitro-benzaldehyde 
• 612-25-9 2-Nitrobenzyl alcohol 
• 14674-35-2 N-(2-nitrobenzylidene)-p-toluenesulfonamide 

Relevant articles and documents

Iron/TEMPO-catalyzed direct aerobic oxidative coupling of methyl-mubstituted N-heteroazaarenes with alcohols

A novel direct oxidative coupling of methyl-substituted N-heteroazaarenes with alcohols has been developed to construct olefins under mild condition. The reaction is catalyzed by Fe(NO3)3·9H2O/TEMPO with oxygen as terminal oxidant. A variety of E-disubstituted olefins bearing diverse functional groups could be obtained selectively in moderate to excellent yields. The reaction is environmentally friendly and ligand-free.

Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes

Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes have been investigated. Series of azaarene derivatives were afforded by this reaction. 2-(Pyridin-2-yl)ethanols with common substituents were formed through the LiNTf2-promoted aldol reaction for the first time. 2-Alkenylpyridines, exclusively in the form of the E isomers, were synthesized in the presence of LiNTf2 cooperated with H2NTf. In the presence of La(Pfb)3 as catalysis, 2-alkenylquinolines were obtained in high yields through the reactions between 2-methylquinolines and aldehydes under air.

Iron-catalyzed C(sp3)-H functionalization of methyl azaarenes: A green approach to azaarene-substituted α- Or β-hydroxy carboxylic derivatives and 2-alkenylazaarenes

Bioactive azaarene-substituted lactic acids, β-hydroxy esters, 3-hydroxy-2H-indol-2-ones, and 2-alkenylazaarenes were prepared in moderate-to-excellent yields via C(sp3)-H functionalization of methyl azaarenes with carbonyl compounds in the presence of iron(ii) acetate as an inexpensive, nontoxic, efficient catalyst. The application of this atom-, step-economic, and environmentally friendly method was demonstrated by a gram-scale synthesis of 3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]benzaldehyde, a key intermediate of leukotriene receptor antagonist (Montelukast).