64350-24-9 Usage
Description
N2-(2-METHYLPROPANOYL)-GUANOSINE, also known as N-Isobutyrylguanosine, is a synthetic nucleoside analog derived from guanosine. It is characterized by its white solid appearance and is primarily utilized in the synthesis of various compounds for research purposes. The chemical structure of N2-(2-METHYLPROPANOYL)-GUANOSINE allows it to be a versatile building block in the creation of complex molecules, particularly in the field of molecular biology and biochemistry.
Uses
Used in Synthesis of Oligonucleotides:
N2-(2-METHYLPROPANOYL)-GUANOSINE is used as a synthetic building block for the creation of 2''-O-(o-nitrobenzyl)-3''-thioguanosine phosphoramidite. N2-(2-METHYLPROPANOYL)-GUANOSINE is then utilized in the formation of oligonucleotides, which serve as substrates for studying the mechanism of RNA catalysis. The application of N2-(2-METHYLPROPANOYL)-GUANOSINE in this context is crucial for advancing our understanding of RNA's role in various biological processes and its potential as a therapeutic target.
Used in Molecular Biology Research:
In the field of molecular biology, N2-(2-METHYLPROPANOYL)-GUANOSINE is used as a key component in the synthesis of modified nucleotides and oligonucleotides. These modified molecules can be employed in various research applications, such as the investigation of gene expression, regulation, and function. The use of N2-(2-METHYLPROPANOYL)-GUANOSINE in this industry enables scientists to develop novel tools and techniques for studying the complex interactions within biological systems.
Used in Drug Development:
N2-(2-METHYLPROPANOYL)-GUANOSINE may also find application in the pharmaceutical industry, particularly in the development of new drugs targeting RNA-based mechanisms. The unique properties of this synthetic nucleoside analog make it a promising candidate for the design of novel therapeutic agents that can modulate RNA function, potentially leading to the treatment of various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 64350-24-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,3,5 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 64350-24:
(7*6)+(6*4)+(5*3)+(4*5)+(3*0)+(2*2)+(1*4)=109
109 % 10 = 9
So 64350-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H19N5O6/c1-5(2)11(23)17-14-16-10-7(12(24)18-14)15-4-19(10)13-9(22)8(21)6(3-20)25-13/h4-6,8-9,13,20-22H,3H2,1-2H3,(H2,16,17,18,23,24)/t6-,8-,9-,13-/m1/s1
64350-24-9Relevant articles and documents
Preparation method of 5′-O-(4,4'-dimethoxytriphenylmethyl)-N2-isobutyryl guanosine
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, (2022/01/10)
The present invention discloses a method for preparing 5 '-O- (4,4'-dimethoxytriphenylmethyl)-N2-isobutyryl guanosine, after the preparation of N2-isobutyryloylguanosine with guanosine as the starting material, dmt-Cl was added to participate in the react
CYCLIC DINUCLEOTIDES AS STING AGONISTS
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Page/Page column 110, (2018/08/20)
Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B
Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives
Vertuani, Silvia,Baldisserotto, Anna,Varani, Katia,Borea, Pier Andrea,De Marcos Maria Cruz, Bonache,Ferraro, Luca,Manfredini, Stefano,Dalpiaz, Alessandro
supporting information; experimental part, p. 202 - 209 (2012/09/07)
Nucleoside derivatives are largely synthesized and tested to investigate their influence on platelet aggregation. It's well known that P2Y receptors play an important role in the regulation of platelet function and, as consequence, in controlling atherothrombotic events. The research of compounds that antagonize P2Y1 and, in particular, P2Y12 receptors is of great interest in the aim to obtain platelet aggregation inhibitors that are effective in the prevention and treatment of arterial thrombosis. In this study we present the synthesis and in vitro metabolic stability in human blood and rat liver homogenate of a new class of nucleoside derivatives, in particular 5′-phosphonate adenosine, inosine, guanosine and thioadenosine analogues also modified at the ribose moiety. On the basis of the results obtained we can hypothesize compounds 4 and 18 to have in vivo a relatively high stability.
