64480-66-6 Usage
Description
2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid is a complex organic compound with a unique molecular structure. It is characterized by its multiple chiral centers and hydroxyl groups, which contribute to its potential biological activities and applications.
Uses
Used in Pharmaceutical Industry:
2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid is used as a potential therapeutic agent for various diseases due to its complex molecular structure and multiple functional groups. Its specific application reason is yet to be determined, but its unique properties make it a promising candidate for drug development.
Used in Chemical Research:
In the field of chemical research, 2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid can be used as a starting material or a building block for the synthesis of more complex molecules with specific biological activities. Its chiral centers and functional groups make it an interesting subject for studying the effects of stereochemistry on molecular properties and reactivity.
Used in Material Science:
The unique structure of 2-[[(4R)-4-[(3R,5S,7S,10R,13R,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid may also find applications in material science, where its properties can be exploited to develop new materials with specific characteristics, such as chiral materials or materials with unique mechanical, electronic, or optical properties.
Biochem/physiol Actions
Secondary bile acid derived from acyl glycine. Glycoursodeoxycholic Acid (GUDCA) is reported to have cytoprotective and anti-inflammatory effects.
Check Digit Verification of cas no
The CAS Registry Mumber 64480-66-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,4,8 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64480-66:
(7*6)+(6*4)+(5*4)+(4*8)+(3*0)+(2*6)+(1*6)=136
136 % 10 = 6
So 64480-66-6 is a valid CAS Registry Number.
InChI:InChI=1/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/t15?,16-,17?,18?,19?,20?,21-,24-,25-,26+/m0/s1
64480-66-6Relevant articles and documents
Glycocholic acid ester, preparation method thereof and preparation method of glycocholic acid
-
, (2021/02/24)
The invention provides a preparation method of glycocholic acid ester, glycocholic acid ester and a preparation method of glycocholic acid, according to the preparation method of glycocholic acid ester, an aza-carbene derivative is used as a condensation reagent, and synthesis of glycocholic acid ester can be efficiently completed through a one-pot method in a wide solvent range. The yield can reach 90% or above, the reaction conditions are mild, and the method can be suitable for preparation of most glycocholic acid esters and can be better suitable for amplification and industrial production.
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.
An improved procedure for the synthesis of glycine and taurine conjugates of bile acids
Tserng,Hachey,Klein
, p. 404 - 407 (2007/10/06)
Glycine and taurine conjugates of 5β cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of choly[1,2 13C2]glycine is described.