64496-78-2

Basic information

• Product Name: Benzoic acid, 2-hydroxy-, 2-chloroethyl ester
• CAS NO: 64496-78-2
• Molecular Formula: C9H9ClO3
• Molecular Weight: 200.622
• Mol File: 64496-78-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-, 2-chloroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-, 2-chloroethyl ester(64496-78-2)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-, 2-chloroethyl ester(64496-78-2)

Safety Data

• Hazardous Substances Data: 64496-78-2(Hazardous Substances Data)

Upstream product

• 67683-95-8 2-acetoxy-benzoic acid-(2-chloro-ethyl ester) 
• 69-72-7 salicylic acid 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 6513-33-3 trimethyl-(2-salicyloyloxy-ethyl)-ammonium; chloride 
• 87-28-5 2-hydroxyethyl salicylate 

Relevant articles and documents

Cytotoxic Activity of Salicylic Acid-Containing Drug Models with Ionic and Covalent Binding

Three different types of drug delivery platforms based on imidazolium ionic liquids (ILs) were synthesized in high preparative yields, namely, the models involving (i) ionic binding of drug and IL; (ii) covalent binding of drug and IL; and (iii) dual binding using both ionic and covalent approaches. Seven ionic liquids containing salicylic acid (SA-ILs) in the cation or/and in the anion were prepared, and their cytotoxicity toward the human cell lines CaCo-2 (colorectal adenocarcinoma) and 3215 LS (normal fibroblasts) was evaluated. Cytotoxicity of SA-ILs was significantly higher than that of conventional imidazolium-based ILs and was comparable to the pure salicylic acid. It is important to note that the obtained SA-ILs dissolved in water more readily than salicylic acid, suggesting benefits of possible usage of traditional nonsoluble active pharmaceutical ingredients in an ionic liquid form.