64520-05-4 Usage
Description
AMITRIPTYLINE METABOLITE (+/-)-, also known as (5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol, is a metabolite of amitriptyline (A633350). Amitriptyline is a dibenzocycloheptadiene derivative and an antidepressant, which also acts as a TrkA and TrkB receptor agonist. This metabolite exhibits neurotrophic and anti-inflammatory activities, making it a promising candidate for various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
AMITRIPTYLINE METABOLITE (+/-)is used as an antidepressant for treating mood disorders and depression. Its neurotrophic and anti-inflammatory properties contribute to its effectiveness in managing the symptoms of these conditions.
Used in Neuroprotection:
AMITRIPTYLINE METABOLITE (+/-)is used as a neuroprotective agent due to its neurotrophic activities. It helps in promoting the growth and survival of neurons, which can be beneficial in treating neurodegenerative diseases and conditions involving neuronal damage.
Used in Anti-inflammatory Applications:
AMITRIPTYLINE METABOLITE (+/-)is used as an anti-inflammatory agent, as it exhibits anti-inflammatory properties. This makes it useful in managing inflammation-related conditions and diseases.
Used in Drinking Water Contaminant Management:
AMITRIPTYLINE METABOLITE (+/-)is listed as a Drinking Water Contaminant Candidate List 3 (CCL 3) compound by the United States Environmental Protection Agency (EPA). This indicates its potential presence in drinking water sources and the need for monitoring and management to ensure water safety and quality.
Biochem/physiol Actions
Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.
Check Digit Verification of cas no
The CAS Registry Mumber 64520-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,5,2 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 64520-05:
(7*6)+(6*4)+(5*5)+(4*2)+(3*0)+(2*0)+(1*5)=104
104 % 10 = 4
So 64520-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+
64520-05-4Relevant articles and documents
Drug Oxidation by Cytochrome P450BM3: Metabolite Synthesis and Discovering New P450 Reaction Types
Ren, Xinkun,Yorke, Jake A.,Taylor, Emily,Zhang, Ting,Zhou, Weihong,Wong, Luet Lok
, p. 15039 - 15047 (2015/10/20)
There is intense interest in late-stage catalytic C-H bond functionalization as an integral part of synthesis. Effective catalysts must have a broad substrate range and tolerate diverse functional groups. Drug molecules provide a good test of these attributes of a catalyst. A library of P450BM3 mutants developed from four base mutants with high activity for hydrocarbon oxidation produced human metabolites of a panel of drugs that included neutral (chlorzoxazone, testosterone), cationic (amitriptyline, lidocaine) and anionic (diclofenac, naproxen) compounds. No single mutant was active for all the tested drugs but multiple variants in the library showed high activity with each compound. The high conversions enabled full product characterization that led to the discovery of the new P450 reaction type of oxidative decarboxylation of an α-hydroxy carboxylic acid and the formation a protected imine from an amine, offering a novel route to α-functionalization of amines. The substrate range and varied product profiles suggest that this library of enzymes is a good basis for developing late-stage C-H activation catalysts.