64648-65-3Relevant articles and documents
Synthesis of indolo[2,1-: A] isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions
Wei, Yun-Long,Chen, Jian-Qiang,Sun, Bo,Xu, Peng-Fei
supporting information, p. 5922 - 5925 (2019/05/27)
We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure. This redox neutral reaction features mild reaction conditions and exceptional functional group tolerance. A series of valuable indolo[2,1-a]isoquinoline derivatives bearing various functional groups were synthesized using this method in good to excellent yields.
A Convenient Modification of the Fischer Indole Synthesis with a Solid Acid
Chandrasekhar, Sosale,Mukherjee, Somnath
supporting information, p. 1018 - 1022 (2015/03/30)
(Chemical Equation Presented). A new one-pot version of the titled reaction involves heating a mixture of a carbonyl compound, a phenylhydrazine, and the cation exchange resin Amberlite IR 120 in refluxing ethanol. A variety of enolizable aldehydes, and ketones and several substituted phenylhydrazines could thus be converted to the corresponding indoles in excellent yields (70-88%). Reaction times were typically 6-10 h, with the resin being then filtered off and the product isolated after minimal workup.
Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors
Kaczor, Agnieszka A.,Karczmarzyk, Zbigniew,Fruziński, Andrzej,Pihlaja, Kalevi,Sinkkonen, Jari,Wiin?maki, Kirsti,Kronbach, Christiane,Unverferth, Klaus,Poso, Antti,Matosiuk, Dariusz
, p. 787 - 795 (2014/01/23)
Non-competitive ligands of kainate receptors have focused significant attention as medicinal compounds because they seem to be better tolerated than competitive antagonists and uncompetitive blocker of these receptors. Here we present structural studies (
