64655-62-5

Basic information

• Product Name: (2-methoxyphenyl)(diphenyl)methanol
• Synonyms: (2-methoxyphenyl)(diphenyl)methanol
• CAS NO: 64655-62-5
• Molecular Weight: 290.362
• Mol File: 64655-62-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-methoxyphenyl)(diphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methoxyphenyl)(diphenyl)methanol(64655-62-5)
• EPA Substance Registry System: (2-methoxyphenyl)(diphenyl)methanol(64655-62-5)

Safety Data

• Hazardous Substances Data: 64655-62-5(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 33921-62-9 2-Methoxy-phenylmagnesium-jodid 
• 64-17-5 ethanol 
• 578-57-4 2-bromoanisole 
• 591-51-5 phenyllithium 
• 529-28-2 4-iodoanisol 
• 60-29-7 diethyl ether 
• 100-66-3 methoxybenzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 6326-60-9 diphenyl(2-hydroxyphenyl)methanol 
• 77-78-1 dimethyl sulfate 
• 944-95-6 isopropyl 2-methoxybenzoate 
• 77408-43-6 2,4,6-trimethylphenyl 2-methoxybenzoate 
• 137600-69-2 2,6-diisopropylphenyl 2-methoxybenzoate 

Downstream Products

• 72824-75-0 ((2-methoxyphenyl)methylene)dibenzene 
• 4970-23-4 2-(diphenylmethyl)phenol 
• 5062-28-2 2-trityl-anisole 
• 857601-28-6 o-monomethoxytrityl chloride 
• 94622-89-6 5-bromo-2-methoxy-α,α-diphenylbenzenemethanol 
• 13561-41-6 N--benzolsulfonamid 
• 119-61-9 benzophenone 
• 92-52-4 biphenyl 
• 2553-04-0 ortho-methoxybenzophenone 
• 86-26-0 2-methoxy-1,1'-biphenyl 
• 64655-66-9 Diphenyl-(2-methoxy-phenyl)-methyl 
• 857591-20-9 2-benzhydryl-4-bromo-anisole 
• 860586-17-0 1,2-bis-(2-methoxy-phenyl)-1,1,2,2-tetraphenyl-ethane 
• 6326-60-9 diphenyl(2-hydroxyphenyl)methanol 

Relevant articles and documents

Sodium-Ketyl Radical Anions by Reverse Pinacol Reaction and Their Coupling with Iodoarenes

Transition-metal-free C-C bond formation between aryl iodides and pinacols is presented. Pinacols are readily transformed by deprotonation with NaH to their Na-pinacolates. C-C-bond homolysis at room temperature generates in situ the corresponding Na-ketyl radical anions which react with various aryl iodides in a homolytic aromatic substitution reaction to form tertiary Na-alcoholates. Protonation eventually provides tertiary alcohols in an unprecedented route.

Palladium-catalyzed arylation of α,α-disubstituted arylmethanols via cleavage of a C-C or a C-H bond to give biaryls

The palladium-catalyzed arylation of α,α-disubstituted arylmethanols with aryl halides proceeds not only via C-H bond cleavage at the ortho-position, but also via cleavage of the sp2-sp3 C-C bond with the liberation of ketones (β-carbon elimination) to give the corresponding biaryls. Both reactions appear to occur through common arylpalladium(II) alcoholate intermediates. The results of systematic studies with respect to which C-C or C-H bond is preferentially cleaved in the arylation are reported. Among the important findings is the selective elimination of ortho-substituted aryl groups even from aryl(diphenyl)methanols due to steric reasons. Thus, various biaryls having ortho-substituents can be produced efficiently by treatment of the corresponding aryl(diphenyl or dimethyl)methanols with aryl bromides and chlorides.

A Practical and Efficient Method for the Construction of the Biphenyl Framework; Nucleophilic Aromatic Substitution on 2-Methoxybenzoates with Aryl Grignard Reagents

Treatment of 2-methoxybenzoic esters derived from 2,6-dialkylphenols with aryl Grignard reagents afforded 1,1'-biphenyl-2-carboxylates in excellent yields.