6469-93-8 Usage
Description
Chlorprothixene hydrochloride is a synthetic antipsychotic agent belonging to the thioxanthene class of drugs. It exhibits neuroleptic and D2 dopamine receptor antagonist properties, making it a valuable compound for the treatment of various psychiatric disorders and research purposes.
Uses
Used in Psychiatry:
Chlorprothixene hydrochloride is used as an antipsychotic agent for the management of symptoms associated with schizophrenia and other psychotic disorders. Its neuroleptic properties help control agitation, delusions, and hallucinations, providing relief to patients suffering from these conditions.
Used in Neurology:
As a D2 dopamine receptor antagonist, Chlorprothixene hydrochloride is utilized in the treatment of neurological disorders characterized by dopamine imbalances, such as Huntington's disease and Tourette syndrome. Its ability to modulate dopamine levels aids in alleviating motor and cognitive symptoms in these patients.
Used in Research:
Chlorprothixene hydrochloride has been employed in scientific studies to investigate its effects on learning and memory in rats. This research helps in understanding the role of dopamine receptors in cognitive functions and the potential therapeutic applications of Chlorprothixene hydrochloride in cognitive disorders.
Therapeutic Function
Tranquilizer
Biological Activity
chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. chlorprothixene is also an inhibitor of gabaa receptor [2]. all of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning.
in vitro
chlorprothixene exihibited strong binding affinities to dopamine and histamine receptors, the ki values of d1, d2, d3, d5 and h1 were 18nm, 2.96 nm, 4.56 nm, 9 nm and 3.75 nm, respectively. chlorprothixene showed little affinity to h3 with the ki value of >1000 nm[1]. in cos-7 cells transiently expressed rat 5-ht7 receptors and hek-293 cells stably transfected with rat 5-ht6, the ki values of chlorprothixene were 5.6 nm and 3 nm, respectively [3]. in vero 76 cells, chlorprothixene treatment inhibited sars-cov replication, with ic50 of 16.7 μm for urbani strain, 13.0 μm for frankfurt-1, 18.5 μm for chuk-w1 and 15.8 μm for toronto-2 [4].
in vivo
in rat brain depressing the release of hypothalamic and hypophyseal hormones, chlorprothixene blocked postsynaptic mesolimbic dopaminergic d1 and d2 receptors [5]. chlorprothixene treatment restored normal ceramide concentrations in murine bronchial epithelial cells, reduced inflammation in the lungs of mice with cystic fibrosis (cf) and prevented infection with pseudomonas aeruginosa [6].
references
[1] von coburg y, kottke t, weizel l, et al. potential utility of histamine h 3 receptor antagonist pharmacophore in antipsychotics[j]. bioorganic & medicinal chemistry letters, 2009, 19(2): 538-542. [2] squires r f, saederup e. clozapine and several other antipsychotic/antidepressant drugs preferentially block the same ‘core’fraction of gaba a receptors[j]. neurochemical research, 1998, 23(10): 1283-1290.[3] roth b l, craigo s c, choudhary m s, et al. binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors[j]. journal of pharmacology and experimental therapeutics, 1994, 268(3): 1403-1410.[4] barnard d l, day c w, bailey k, et al. is the anti-psychotic, 10-(3-(dimethylamino) propyl) phenothiazine (promazine), a potential drug with which to treat sars infections: lack of efficacy of promazine on sars-cov replication in a mouse model[j]. antiviral research, 2008, 79(2): 105-113.[5] gey k f, pletscher a. influence of chlorpromazine and chlorprothixene on the cerebral metabolism of 5-hydroxytryptamine, norepinephrine and dopamine[j]. journal of pharmacology and experimental therapeutics, 1961, 133(1): 18-24.[6] becker k a, riethmuller j, luth a, et al. acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis[j]. american journal of respiratory cell and molecular biology, 2010, 42(6): 716-724.]
Check Digit Verification of cas no
The CAS Registry Mumber 6469-93-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,6 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6469-93:
(6*6)+(5*4)+(4*6)+(3*9)+(2*9)+(1*3)=128
128 % 10 = 8
So 6469-93-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H18ClNS.ClH/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18;/h3-4,6-10,12H,5,11H2,1-2H3;1H
