65017-76-7

Basic information

• Product Name: Benzamide, N-methyl-4-(trifluoromethyl)-
• CAS NO: 65017-76-7
• Molecular Formula: C9H8F3NO
• Molecular Weight: 203.164
• Mol File: 65017-76-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzamide, N-methyl-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-methyl-4-(trifluoromethyl)-(65017-76-7)
• EPA Substance Registry System: Benzamide, N-methyl-4-(trifluoromethyl)-(65017-76-7)

Safety Data

• Hazardous Substances Data: 65017-76-7(Hazardous Substances Data)

Upstream product

• 455-24-3 4-trifluoromethylbenzoic acid 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 1891-90-3 p-trifluoromethylbenzamide 
• 593-51-1 methylamine hydrochloride 
• 67-56-1 methanol 
• 66046-34-2 4-(trifluoromethyl)benzaldehyde oxime 
• 68-12-2 N,N-dimethyl-formamide 
• 116332-61-7 N-methoxy-N-methyl-4-trifluoromethylbenzamide 
• 74-89-5 methylamine 
• 1370441-14-7 2,2,2-trichloro-1-(4-(trifluoromethyl)phenyl)ethanone 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 455-13-0 4-Iodobenzotrifluoride 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 1235478-91-7 2-methyl-3,4-diphenyl-6-(trifluoromethyl)isoquinolin-1(2H)-one 
• 1427042-18-9 C₂₃H₂₁NO₂ 
• 1427042-12-3 (E)-2-(1,2-diphenylvinyl)-N-methyl-4-(trifluoromethyl)benzamide 
• 1613319-99-5 2-(methylcarbamoyl)-5-(trifluoromethyl)phenyl 4-chlorobenzoate 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 

Relevant articles and documents

The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroeth

Dealkoxylation ofN-alkoxyamides without an external reductant driven by Pd/Al cooperative catalysis

Lewis acid-assisted palladium-catalysed dealkoxylation ofN-alkoxyamides has been developed. This reaction proceeded smoothly with a range ofN-alkoxyamides in the absence of an external reductant, thereby establishing a convenient and reductant-free protocol. In addition, a gram-scale reaction could be achieved. Preliminary mechanistic investigations indicated that β-hydrogen elimination from a palladium alkoxide intermediate generated an intramolecular hydride source.

Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol

An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.