6515-37-3 Usage
Description
4'-Hydroxyflavanone, with the chemical name 2-(4-hydroxyphenyl)-5,7-dihydroxychroman-4-one, is a naturally occurring flavanone compound. It is characterized by its unique structure, which includes a chroman-4-one core with a phenyl group at the 2-position and hydroxyl groups at the 4' and 5,7 positions. 4'-HYDROXYFLAVANONE has garnered significant interest due to its potential biological activities and therapeutic properties.
Source:
4'-Hydroxyflavanone can be found in various plant sources, particularly in the Rutaceae family, and is often isolated from citrus fruits and their peels.
Production Methods:
The production of 4'-Hydroxyflavanone typically involves extraction and purification processes from natural sources. Various techniques, such as solvent extraction, chromatography, and crystallization, can be employed to obtain the compound in a pure form.
Uses
Used in Pharmaceutical Industry:
4'-Hydroxyflavanone is used as an antitumor agent, specifically studied for its strong aromatase inhibitory activity against estrogen-dependent breast cancer. It has the potential to modulate the hormonal environment in breast cancer cells, thereby inhibiting their growth and proliferation.
Used in Cancer Research:
In the field of cancer research, 4'-Hydroxyflavanone serves as a valuable compound for investigating the molecular mechanisms underlying its antitumor effects. Studies on this compound can provide insights into the development of novel therapeutic strategies for estrogen-dependent breast cancer and other hormone-related cancers.
Used in Drug Development:
4'-Hydroxyflavanone holds promise as a lead compound in the development of new pharmaceuticals targeting estrogen-dependent cancers. Its unique structure and biological activity make it an attractive candidate for further optimization and drug design efforts, potentially leading to the creation of more effective and targeted cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 6515-37-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,5,1 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6515-37:
(6*6)+(5*5)+(4*1)+(3*5)+(2*3)+(1*7)=93
93 % 10 = 3
So 6515-37-3 is a valid CAS Registry Number.
6515-37-3Relevant articles and documents
Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization
Son, Seung Hwan,Cho, Yang Yil,Yoo, Hyung-Seok,Lee, Soo Jin,Kim, Young Min,Jang, Hyu Jeong,Kim, Dong Hwan,Shin, Jeong-Won,Kim, Nam-Jung
, p. 14000 - 14006 (2021/04/22)
Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.
Synthesis, Structure, and Anti-Inflammatory Activity of Functionally Substituted Chalcones and Their Derivatives
Nurkenov,Ibraev,Schepetkin,Khlebnikov,Seilkhanov,Arinova,Isabaeva
, p. 1360 - 1367 (2019/08/21)
Functionally substituted chalcones, pyrazolines, and flavonones have been synthesized. Their structure has been studied by means of 1H and 13C NMR spectroscopy, including COSY and HMQC experiments. Anti-inflammatory activity of the s
Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents
Anand, Preet,Singh, Baldev
, p. 1648 - 1659 (2013/07/26)
This study was designed to synthesize and evaluate flavanone derivatives with phenylcarbamate moiety as potent acetylcholinesterase (AChE) inhibitors and anti-amnestic agents for management of AD. The synthesis of carbamate-substituted flavanone derivativ
