65440-83-7

Basic information

• Product Name: O-(2-methylphenyl)hydroxylamine
• Synonyms: O-(2-methylphenyl)hydroxylamine
• CAS NO: 65440-83-7
• Molecular Weight: 123.155
• Mol File: 65440-83-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: O-(2-methylphenyl)hydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: O-(2-methylphenyl)hydroxylamine(65440-83-7)
• EPA Substance Registry System: O-(2-methylphenyl)hydroxylamine(65440-83-7)

Safety Data

• Hazardous Substances Data: 65440-83-7(Hazardous Substances Data)

Upstream product

• 16419-60-6 2-Methylphenylboronic acid 
• 1239023-38-1 C₂₆H₁₅F₁₇N₂O₄ 
• 88-72-2 1-methyl-2-nitrobenzene 

Downstream Products

• 937716-68-2 (E)-1-phenylethanone O-(2-methylphenyl)oxime 
• 14893-87-9 7-methyl-2,3-diphenylbenzofuran 
• 1443440-54-7 (2-methyl-N-phenoxy)acetamide 
• 4072-08-6 (2-hydroxy-3-methylphenyl)(phenyl)methanone 
• 60344-91-4 2-(2'-hydroxy-3'-methylphenyl)benzoxazole 
• 56048-53-4 2-(2'-hydroxy-3'-methylphenyl)benzothiazole 
• 151830-35-2 methyl N-hydroxy-2-methylphenylcarbamate 
• 201663-83-4 N-o-Tolyloxy-benzamide 
• 95-71-6 2-methylbenzene-1,4-diol 

Relevant articles and documents

Synthesis of ortho-phenolic sulfilimines via an intermolecular sulfur atom transfer cascade reaction

To expand the toolbox for the synthesis of ortho-phenolic sulfilimines, sigmatropic rearrangements were introduced to the field of sulfilimine chemistry. Herein we report a N-H sulfenylation/[2,3]-sigmatropic rearrangement cascade reaction. This mild reaction enables commercially available thiols to serve as the sulfenylation reagent and generates water as the sole byproduct. Moreover, the reaction has a wide substrate scope and can be conducted on a gram scale with excellent reaction efficiency.

Dual Directing-Groups-Assisted Redox-Neutral Annulation and Ring Opening of N-Aryloxyacetamides with 1-Alkynylcyclobutanols via Rhodium(III)-Catalyzed C-H/C-C Activations

A cascade [3 + 2] annulation and ring opening of N-aryloxyacetamides with 1-alkynylcyclobutanols via Rh(III)-catalyzed redox-neutral C-H/C-C activations using internal oxidative O-NHAc and -OH as the dual directing groups has been achieved. This reaction provided an efficient and regioselective approach to benzofuran derivatives with good functional group compatibility and high yields.

Rhodium(III)-catalysed cascade [3 + 2] annulation of: N -aryloxyacetamides with 3-(hetero)arylpropiolic acids: Synthesis of benzofuran-2(3 H)-ones

Herein, a cascade [3 + 2] annulation of N-aryloxyacetamides with 3-(hetero)arylpropiolic acids affording benzofuran-2(3H)-ones via rhodium(iii)-catalyzed redox-neutral C-H functionalization/isomerization/lactonization using an internal oxidative directing group O-NHAc was achieved. This catalytic system provides a regio- and stereoselective approach to synthesize (Z)-3-(amino(aryl)methylene)benzofuran-2(3H)-ones with exclusive Z configuration selectivity, acceptable yields and good functional group tolerance. Preliminary investigations on ultraviolet-visible and fluorescence behaviors reveal that the annulation products may be applied as a promising fluorescent probe for sensing metal cations, especially for cerium (Ce3+).