65678-07-1

Basic information

• Product Name: TYRPHOSTIN AG 1024
• Synonyms: AG-1024 (Tyrphostin);2-(3-broMo-5-tert-butyl-4-hydroxybenzylidene)Malononitrile;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;AGS 200;Tyrphostin;2-[[3-Bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile AGS 200;HY-10253
• CAS NO: 65678-07-1
• Molecular Formula: C₁₄H₁₃BrN₂O
• Molecular Weight: 305.174
• Mol File: 65678-07-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 379.8°Cat760mmHg
• Flash Point: 183.5°C
• Appearance: yellow/solid
• Density: 1.42g/cm³
• Vapor Pressure: 2.61E-06mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: −20°C
• Solubility: DMSO: soluble
• CAS DataBase Reference: TYRPHOSTIN AG 1024(CAS DataBase Reference)
• NIST Chemistry Reference: TYRPHOSTIN AG 1024(65678-07-1)
• EPA Substance Registry System: TYRPHOSTIN AG 1024(65678-07-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 65678-07-1(Hazardous Substances Data)

Usage

Description

TYRPHOSTIN AG 1024, also known as AG-1024, is a selective and potent inhibitor of the insulin-like growth factor 1 receptor (IGF-1R). It functions by antagonizing the binding of insulin-like growth factor 1 (IGF-1) to its receptor, thereby disrupting the signaling pathways that promote cell growth, transformation, and survival. This makes AG-1024 a valuable compound in the study and potential treatment of cancer.
Used in Pharmaceutical Industry:
TYRPHOSTIN AG 1024 is used as an anticancer agent for its ability to inhibit the proliferation of cancer cells and induce apoptosis. It targets the IGF-1R, which is often overexpressed in various types of cancer, and plays a crucial role in tumor growth and resistance to apoptosis. By inhibiting the IGF-1R, AG-1024 can potentially reduce the tumorigenic potential of cancer cells and increase their susceptibility to cell death.
TYRPHOSTIN AG 1024 is also used as a research tool for studying the role of the IGF-1R in cellular processes. Its selective inhibition of IGF-1R autophosphorylation and the subsequent effects on the PI3K/Akt signaling pathway make it a valuable compound for investigating the mechanisms of cell growth, transformation, and survival in the context of cancer development and progression.

references

[1] párrizas m1, gazit a, levitzki a, wertheimer e, leroith d. specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. endocrinology. 1997 apr;138(4):1427-33.[2] fan p1, agboke fa1, mcdaniel re1, sweeney ee1, zou x1, creswell k1, jordan vc2.inhibition of c-src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. eur j cancer. 2014 jan; 50(2):457-68.

InChI:InChI=1/C14H13BrN2O/c1-14(2,3)11-5-9(4-10(7-16)8-17)6-12(15)13(11)18/h4-6,18H,1-3H3

Upstream product

• 65678-11-7 3-(1,1-Dimethylethyl)-4-hydroxy-benzaldehyde 
• 88-18-6 2-tert-Butylphenol 
• 65678-06-0 3-bromo-5-tert-butyl-4-hydroxybenzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

Compositions for killing internal parasites containing 3-tert-alkyl-4-hydroxy-5-halo-benzylidene-malonitriles

A compound of the general formula I STR1 wherein R1 is halogen, R4 is a highly branched alkyl group, R2 and R3 which may be the same or different are hydrogen or halogen atoms or lower alkyl groups.