6610-25-9 Usage
Description
Arachidonic acid sodium salt, also known as eicosatetraenoic acid sodium salt, is a polyunsaturated omega-6 fatty acid that serves as a precursor to various eicosanoids, which are important signaling molecules in the body. It is an essential component of cell membranes and plays a crucial role in various physiological processes, including inflammation, blood clotting, and immune response.
Uses
Used in Biochemical Assays:
Arachidonic acid sodium salt is used as a substrate in assays to measure the activity of oxidizing enzymes, such as cyclooxygenase, which are involved in the synthesis of prostaglandins and other eicosanoids. These assays help in understanding the role of these enzymes in various physiological and pathological conditions.
Used in Platelet Inhibition Assays:
Arachidonic acid sodium salt is used in assays to determine platelet inhibition in whole blood. This helps in evaluating the effectiveness of antiplatelet drugs and understanding the mechanisms of platelet aggregation and blood clotting.
Used in Cancer Research:
Arachidonic acid has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). This suggests its potential role in the development and progression of prostate cancer, as Ras proteins are often mutated in various cancers, leading to uncontrolled cell growth.
Used in Immunology Research:
Arachidonic acid has been shown to enhance the formation of lipid bodies in human mast cells. This finding is significant in immunology research, as mast cells play a crucial role in immune responses, particularly in allergic reactions and inflammation.
Biochem/physiol Actions
Released arachidonic acid (AA) reacts with molecular oxygen nonenzymatically, through oxidative stress, and enzymatically through the action of oxygenase enzymes. AA is oxidized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. Cellular uptake of arachidonic acid is energy dependent and involves protein-facilitated transport across the plasma membrane.
Check Digit Verification of cas no
The CAS Registry Mumber 6610-25-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,1 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6610-25:
(6*6)+(5*6)+(4*1)+(3*0)+(2*2)+(1*5)=79
79 % 10 = 9
So 6610-25-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22;/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22);/q;+1/p-1/b7-6-,10-9-,13-12-,16-15-;
