6610-35-1

Basic information

• Product Name: 2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 4-methylpiperazine-1-carbodithioate
• Synonyms: 1-Piperazinecarbodithioic acid, 4-methyl-, 2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl ester; 2-(3,4-Dihydroquinolin-1(2H)-yl)-2-oxoethyl 4-methylpiperazine-1-carbodithioate
• CAS NO: 6610-35-1
• Molecular Formula: C₈H₁₀ClN₃S
• Molecular Weight: 349.514
• Mol File: 6610-35-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 542.7°C at 760 mmHg
• Flash Point: 282°C
• Density: 1.27g/cm³
• Vapor Pressure: 7.7E-12mmHg at 25°C
• Refractive Index: 1.64
• CAS DataBase Reference: 2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 4-methylpiperazine-1-carbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 4-methylpiperazine-1-carbodithioate(6610-35-1)
• EPA Substance Registry System: 2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl 4-methylpiperazine-1-carbodithioate(6610-35-1)

Safety Data

• Hazardous Substances Data: 6610-35-1(Hazardous Substances Data)

Upstream product

• 18967-44-7 o-chlorobenzyl isothiocyanate 
• 89-97-4 2-CHLOROBENZYLAMINE 
• 74788-68-4 (2-Chloro-benzyl)-dithiocarbamic acid methyl ester 

Downstream Products

• 1075220-51-7 indole-3-carboxaldehyde N⁽⁴⁾-(2-chlorobenzyl)thiosemicarbazone 
• 1078661-98-9 C₂₂H₂₁ClN₆O₃S 
• 1019283-65-8 C₁₈H₁₈ClN₃S 

Relevant articles and documents

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Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives

A series of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4]triazin-4-yl thiosemicarbazide derivatives 3-22 were prepared and evaluated in vitro against HM1:1MSS strain of Entamoeba histolytica, to identify the compounds for antiamoebic activity. They exhibited antiamoebic activity in the range (IC 50 = 0.81-7.31 μM). The results were compared to the activity of known drug metronidazole. It is inferred from the in vitro studies that the compounds 10, 11, 17 and 18 were found to be significantly better inhibitors of E. histolytica since IC50 values in the μM range elicited by these compounds are much lower than metronidazole. Besides, compounds 11 and 17 have shown the most promising antiamoebic activity (IC50 = 0.81 μM of 11, IC50 = 0.84 μM of 17 versus IC50 = 1.81 μM of metronidazole). The study suggests the possibility of developing triazine analogues as potential drug candidates for antiamoebic activity.