66354-88-9

Basic information

• Product Name: 7-METHOXY-2-PHENYL-1H-INDOLE
• Synonyms: 1H-INDOLE, 7-METHOXY-2-PHENYL-;7-METHOXY-2-PHENYL-1H-INDOLE
• CAS NO: 66354-88-9
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.274
• Mol File: 66354-88-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-METHOXY-2-PHENYL-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-2-PHENYL-1H-INDOLE(66354-88-9)
• EPA Substance Registry System: 7-METHOXY-2-PHENYL-1H-INDOLE(66354-88-9)

Safety Data

• Hazardous Substances Data: 66354-88-9(Hazardous Substances Data)

Usage

General Description

7-Methoxy-2-phenyl-1H-indole is a chemical compound with the molecular formula C15H13NO. It is a derivative of indole and belongs to the class of organic compounds known as tryptamines. 7-Methoxy-2-phenyl-1H-indole is commonly used in the field of medicinal chemistry for its potential pharmacological properties, particularly in the development of pharmaceutical drugs. Tryptamines have been studied for their various effects on the central nervous system, including psychoactive and hallucinogenic properties. 7-METHOXY-2-PHENYL-1H-INDOLE is also of interest in research related to serotonin receptors and their involvement in psychiatric and neurological disorders. Further studies are needed to fully understand its potential therapeutic significance and biological activity.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
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• 98-86-2 acetophenone 
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• 396094-82-9 2-[2'-(N-Boc-amino)-3'-methoxyphenyl]-1,3-dithiane 
• 496043-62-0 2-(2'-amino-3'-methoxyphenyl)-1,3-dithiane 
• 358657-78-0 2-(3'-methoxy-2'-nitrophenyl)-1,3-dithiane 

Downstream Products

• 3177-80-8 2-amino-3-methoxybenzoic acid 
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• 857193-93-2 2-benzoylamino-3-methoxy-benzoic acid 
• 500893-17-4 N-(2-formyl-4-methoxyphenyl)benzamide 
• 857764-45-5 7-methoxy-1-methyl-2-phenyl-1H-indole 

Relevant articles and documents

Regioselective mercury(I)/palladium(II)-catalyzed single-step approach for the synthesis of imines and 2-substituted indoles

An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cycliza-tion of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H acti-vation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.

Pd(II)/Bu4NBr/DMSO catalytic system for practical synthesis of indoles and pyrroles from imines through aerobic dehydrogenative cyclization

N-Aryl- and N-allylimines derived typically from substituted acetophenones undergo palladium(II)-catalyzed dehydrogenative cyclization reactions in the presence of tetrabutylammonium bromide and molecular oxygen in DMSO to afford indole and pyrrole deriva

Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: Indole synthesis from anilines and ketones

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.