6642-37-1

Basic information

• Product Name: N-(4-methoxyphenyl)-2-methyl-propanamide
• Synonyms: N-(4-methoxyphenyl)-2-methyl-propanamide;PropanaMide, N-(4-Methoxyphenyl)-2-Methyl-
• CAS NO: 6642-37-1
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Mol File: 6642-37-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 358.3°C at 760 mmHg
• Flash Point: 170.5°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.539
• PKA: 14.28±0.70(Predicted)
• CAS DataBase Reference: N-(4-methoxyphenyl)-2-methyl-propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-2-methyl-propanamide(6642-37-1)
• EPA Substance Registry System: N-(4-methoxyphenyl)-2-methyl-propanamide(6642-37-1)

Safety Data

• Hazardous Substances Data: 6642-37-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO2/c1-8(2)11(13)12-9-4-6-10(14-3)7-5-9/h4-8H,1-3H3,(H,12,13)

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Downstream Products

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Relevant articles and documents

Enantioselective One-Pot Synthesis of β-Lactams from Achiral 2-Pyridylthioesters and Aromatic Imines

The enolates derived from 2-pyridylthioesters by reaction with BCl3*SMe2 and enantiomerically pure aminoalcohols react with aromatic imines in an enantioselective fashion (ee up to 78percent) to afford β-lactams in a convenient one-pot procedure.

Preparation method of N-aryl amide compound

The invention discloses a preparation method of an N-aryl amide compound, which comprises the following steps: (1) putting diaryliodonium salt and Cu(OAc)2 into a Schlenk tube provided with a magneticstirring rod; (2) sequentially adding DCE, H2O and nitrile by using an injector, sealing the Schlenk tube, and stirring for reaction at 80 DEG C; (3) cooling the obtained solution to room temperature, and performing extraction with EtOAc; and combining organic layers, performing washing with saline water, and performing drying with anhydrous Na2SO4; and (4) removing volatile matters in vacuum, and purifying residues through column chromatography to obtain the N-aryl amide compound. Through a large number of experiments, a substrate with a simple structure is screened, the reaction conditionsare mild, the yield is high, the pollution is small, and the application prospect is wide.

Rapidly Activating Pd-Precatalyst for Suzuki-Miyaura and Buchwald-Hartwig Couplings of Aryl Esters

Esters are valuable electrophiles for cross-coupling due to their ubiquity and ease of synthesis. However, harsh conditions are traditionally required for the effective cross-coupling of ester substrates. Utilizing a recently discovered precatalyst, Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions involving cleavage of the C(acyl)-O bond of aryl esters that proceed under mild conditions are reported. The Pd(II) precatalyst is highly active because it is reduced to the Pd(0) active species more rapidly than previous precatalysts.