6652-04-6

Basic information

• Product Name: 1-nitroso-4-phenylpiperidine
• Synonyms: 1-nitroso-4-phenylpiperidine
• CAS NO: 6652-04-6
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.27
• Mol File: 6652-04-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 325.75°C (rough estimate)
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.0815 (rough estimate)
• Vapor Pressure: 7.3E-05mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• CAS DataBase Reference: 1-nitroso-4-phenylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitroso-4-phenylpiperidine(6652-04-6)
• EPA Substance Registry System: 1-nitroso-4-phenylpiperidine(6652-04-6)

Safety Data

• Hazardous Substances Data: 6652-04-6(Hazardous Substances Data)

Usage

Classification

Piperidine derivative an organic compound with a six-membered heterocyclic ring containing a nitrogen atom.

Nitroso group presence

Potential applications in pharmaceutical research nitroso compounds have been studied for their potential anticancer, antimicrobial, and anti-inflammatory properties.

Phenyl group

Contains a six-carbon aromatic ring this structural feature can confer specific chemical properties to the compound.

Scientific interest and investigation

Due to its interesting chemical and potential pharmaceutical properties, 1-nitroso-4-phenylpiperidine is a subject of ongoing research and study.

InChI:InChI=1/C11H14N2O/c14-12-13-8-6-11(7-9-13)10-4-2-1-3-5-10/h1-5,11H,6-9H2

Upstream product

• 771-99-3 4-phenylpiperidine 

Relevant articles and documents

Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired α-amino oxime derivatives were obtained in a one-pot tandem N-nitrosation and photoaddition sequence.

Substrate promiscuity of ortho-naphthoquinone catalyst: Catalytic aerobic amine oxidation protocols to deaminative cross-coupling and n-nitrosation

ortho-Naphthoquinone-based organocatalysts have been identified as versatile aerobic oxidation catalysts. Primary amines were readily cross-coupled with primary nitroalkanes via deaminative pathway to give nitroalkene derivatives in good to excellent yields. Secondary and tertiary amines were inert to ortho-naphthoquinone catalysts; however, secondary nitroalkanes were readily converted by ortho-naphthoquinone catalysts to the corresponding nitrite species that in situ oxidized the amines to the corresponding N-nitroso compounds. Without using harsh oxidants in a stoichiometric amount, the present catalytic aerobic oxidation protocol utilizes the substrate promiscuity feature to provide a facile access to amine oxidation products under mild reaction conditions.