6686-70-0

Basic information

• Product Name: DESTRUXIN A
• Synonyms: DESTRUXIN A;destruxin A from metarhizium anisopliae;3-Ethenylcyclo(D-Lac-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-βAla-);N-[N-[(2R)-1-Oxo-2-hydroxy-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;N-[N-[(R)-2-Hydroxy-1-oxo-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone;Destruxin A from Metarrhizium anisopliae;Destruxin A, 98%, from Metarhizium anisopliae
• CAS NO: 6686-70-0
• Molecular Formula: C29H47N5O7
• Molecular Weight: 577.71
• Product Categories: Apoptosis and Cell Cycle;Cell Cycle;Cell Cycle Regulators
• Mol File: 6686-70-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 188-189 °C
• Boiling Point: 875.6°C at 760 mmHg
• Flash Point: 483.3°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 3.74E-31mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: −20°C
• PKA: 13.53±0.70(Predicted)
• CAS DataBase Reference: DESTRUXIN A(CAS DataBase Reference)
• NIST Chemistry Reference: DESTRUXIN A(6686-70-0)
• EPA Substance Registry System: DESTRUXIN A(6686-70-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-48
• Safety Statements: 26-36-45
• WGK Germany: 3
• RTECS: HH1500000
• Hazardous Substances Data: 6686-70-0(Hazardous Substances Data)

Usage

Description

Destruxin A is a secondary metabolite produced by the entomopathogenic fungus Metarrhizium anisopliae. It exhibits potent insecticidal activity and has been extensively studied for its potential applications in pest control.

Uses

Used in Pest Control Industry:
Destruxin A is used as a biopesticide for the control of various agricultural pests, particularly Rhipicephalus (Boophilus) microplus, a tick species that causes significant economic losses in livestock farming. Its insecticidal properties make it an effective alternative to chemical pesticides, reducing the environmental impact and promoting sustainable agriculture.
Used in Research and Development:
In the field of entomology and insect physiology, Destruxin A is used as a transport inhibitor in Drosophila melanogaster (fruit flies). This application aids researchers in understanding the mechanisms of insecticide action and developing new strategies for pest control. By studying the effects of Destruxin A on insect models, scientists can gain insights into the molecular targets and potential resistance mechanisms, ultimately contributing to the development of more effective and environmentally friendly pest management solutions.

Biochem/physiol Actions

Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.

InChI:InChI=1/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)