669738-91-4

Basic information

• Product Name: Butanoic acid, 2-hydroxy-3-(phenylmethoxy)-, (2S,3R)-
• CAS NO: 669738-91-4
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Mol File: 669738-91-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-hydroxy-3-(phenylmethoxy)-, (2S,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-hydroxy-3-(phenylmethoxy)-, (2S,3R)-(669738-91-4)
• EPA Substance Registry System: Butanoic acid, 2-hydroxy-3-(phenylmethoxy)-, (2S,3R)-(669738-91-4)

Safety Data

• Hazardous Substances Data: 669738-91-4(Hazardous Substances Data)

Upstream product

• 15260-10-3 N-Boc-O-benzyl-L-threonine 
• 4378-10-3 O-benzyl-L-threonine 

Downstream Products

• 142681-57-0 (2R,3R)-3-(benzyloxy)butane-1,2-diol 
• 462117-82-4 C₅₉H₈₃N₇O₁₅ 
• 462117-84-6 C₅₉H₈₂N₆O₁₆ 
• 462117-74-4 (S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester 
• 462117-75-5 (S)-1-{(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester 
• 462117-87-9 (S)-1-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester 
• 462117-88-0 (S)-1-{(S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyloxy]-4-methyl-pentanoyl}-pyrrolidine-2-carboxylic acid (1S,2R)-2-benzyloxy-1-benzyloxycarbonyl-propyl ester 
• 462117-73-3 H-Pro-Ψ[CO-O]-Thr(Bzl)-OBzl 
• 155245-34-4 (2S,3R)-3-Benzyloxy-2-hydroxy-butyric acid benzyl ester 

Relevant articles and documents

Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation

There is an urgent need for novel therapeutic approaches to treat Alzheimer's disease (AD) with the ability to both alleviate the clinical symptoms and halt the progression of the disease. AD is characterized by the accumulation of amyloid-β (Aβ) peptides

Facile synthesis of α-hydroxy carboxylic acids from the corresponding α-amino acids

An effective and improved procedure is developed for the synthesis of α-hydroxy carboxylic acids by treatment of the corresponding protonated α-amino acid with tert-butyl nitrite in 1,4-dioxane-water. The amino moiety must be protonated and located α to a carboxylic acid function in order to undergo initial diazotization and successive hydroxylation, since neither β-amino acids nor acid derivatives such as esters and amides undergo hydroxylations. The method is successfully applied for the synthesis of 18 proteinogenic amino acids.

Synthesis of All Nineteen Appropriately Protected Chiral α-Hydroxy Acid Equivalents of the α-Amino Acids for Boc Solid-Phase Depsi-Peptide Synthesis

(Equation presented) The preparation of depsi-peptides, amide-to-ester-substituted peptides used to probe the role of hydrogen bonding in protein folding energetics, is accomplished by replacing specific L-α-amino acid residues by their α-hydroxy acid cou