67-07-2 Usage
Description
Creatine phosphate, also known as phosphocreatine, is a high-energy compound found in cells, particularly in muscles and the brain. It plays a crucial role in energy storage and release, acting as a rapid source of energy for short-term, high-intensity activities.
Uses
Used in Synthesis of Hydroxyapatite Nanorod/Nanosheets:
Creatine phosphate is used as a precursor in the synthesis of hydroxyapatite nanorods and nanosheets, which are essential components in the development of advanced materials for various applications, including bone grafting and drug delivery systems.
Used in Treatment of Heart and Brain Ischemia:
Creatine phosphate is used as a therapeutic agent in the treatment of heart and brain ischemia. It helps improve energy supply to the affected tissues, reducing the damage caused by insufficient blood flow and oxygen supply. This application takes advantage of creatine phosphate's ability to rapidly provide energy to cells under stress, promoting healing and recovery.
Enzyme inhibitor
This phosphagen (FW = 211.11 g/mol; CAS 67-07-2; 922-32-7 for disodium salt), known almost as commonly as creatine phosphate, is the primary cytosolic phosphoryl donor for the resynthesis of MgATP from MgADP through the action of creatine kinase in vertebrates and some invertebrates. While abundant in skeletal and cardiac muscle (40-60 mM), nonmuscle cells contain 3-5 mM, and some fungi (e.g., Candida) have intermediate levels of this metabolite. Note: The reported inhibitory action by creatine kinase is often due to impurities (e.g., the inhibition of 5’- nucleotidase is due to an impurity in the commercial phosphocreatine). The reported inhibition of AMP deaminase is due mainly to the presence of pyrophosphate. Phosphocreatine is a hygroscopic solid and very soluble in water. Unstable in acid, all is hydrolyzed after one minute at 100°C in 1.0 M HCl, and half is hydrolyzed in 4 min at 25°C in 0.5 M HCl. Molybdate and certain buffers reportedly accelerate hydrolysis. Hydrolysis is slow under slightly alkaline conditions (e.g., pH 7.8). Nevertheless, solutions should always be freshly prepared and stored frozen. Target(s): adenylate cyclase; AMP deaminase; glutamine synthetase; H+-extrusion by plasma membrane ATPase; NADH peroxidase; phosphofructokinase; and thiamin-phosphate diphosphorylase.
Check Digit Verification of cas no
The CAS Registry Mumber 67-07-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 67-07:
(4*6)+(3*7)+(2*0)+(1*7)=52
52 % 10 = 2
So 67-07-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)
67-07-2Relevant articles and documents
Synthesis technology of creatine phosphate sodium
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Paragraph 0061; 0062; 0064, (2018/03/01)
The invention provides a synthesis technology of creatine phosphate sodium. The technology comprises the following steps: reacting creatine monohydrate with phosphoric acid in ethanol to obtain ethanol-insoluble creatine phosphate; and carrying out a refluxing reaction on the creatine phosphate in an ethyl acetate solvent with 4-dimethylpyridine (DMAP) as a creatine phosphorylation reaction catalyst and dicyclohexylcarbodiimide (DCC) as a reaction dehydrant to obtain phosphorylated creatine, carrying out alkaline hydrolysis on the phosphorylated creatine in an aqueous solution of sodium hydroxide, filtering the obtained alkaline hydrolysis product, and adding ethanol to the obtained filtrate to obtain the creatine phosphate sodium. The whole technology is a normal-temperature and normal-pressure technology basically, and has the advantages of low energy consumption and high single-step reaction yield. Water-insoluble 1,3-dicyclohexylurea (DCU) completely formed by the DCC dehydrant in the alkaline hydrolysis workshop section can be filtered out, and the ethanol is directly added to the aqueous solution to precipitate a high-quality creatine phosphate disodium salt. The ethyl acetate and anhydrous ethanol used in the technology can be recycled. The discharge capacity of wastewater in the whole technology is small.
Carotenoid ester analogs or derivatives for controlling C-reactive protein levels
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, (2008/06/13)
A method of controlling (e.g., influencing or affecting) C-reactive protein levels in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.