67-42-5 Usage
Description
Ethylenebis(oxyethylenenitrilo)tetraacetic acid, also known as EGTA or Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid, is a chelating agent that forms stable complexes with calcium ions, particularly in the presence of magnesium. It is a versatile compound with applications in various fields due to its ability to bind and stabilize metal ions.
Uses
Used in Pharmaceutical Aid:
Ethylenebis(oxyethylenenitrilo)tetraacetic acid is used as a pharmaceutical aid, specifically as EGTA, for its chelating properties that help in stabilizing and delivering active pharmaceutical ingredients.
Used in Analytical Chemistry:
As a chelating agent, Ethylenebis(oxyethylenenitrilo)tetraacetic acid is used for the determination of calcium in the presence of magnesium, providing accurate and reliable measurements in analytical chemistry.
Used in Experimental Treatment:
Ethylenebis(oxyethylenenitrilo)tetraacetic acid can be used experimentally for treating animals with cerium poisoning, showcasing its potential in detoxification processes.
Used in Chemical Separation:
Ethylenebis(oxyethylenenitrilo)tetraacetic acid is useful in the separation of thorium from monazite, an important process in the extraction and purification of valuable elements.
Used in Buffer Solutions:
Ethylenebis(oxyethylenenitrilo)tetraacetic acid acts as a buffer, maintaining stable pH levels in various chemical and biological processes.
Used in Protein Purification:
Due to its chelating properties, Ethylenebis(oxyethylenenitrilo)tetraacetic acid is used in protein purification, helping to isolate and concentrate target proteins for further study and application.
Biological Activity
Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Safety Profile
Poison by
intraperitoneal route. Moderately toxic by
ingestion. When heated to decomposition it
emits toxic fumes of NOx. See also
GLYCOL ETHERS.
Purification Methods
Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]
Check Digit Verification of cas no
The CAS Registry Mumber 67-42-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 67-42:
(4*6)+(3*7)+(2*4)+(1*2)=55
55 % 10 = 5
So 67-42-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)/p-2
67-42-5Relevant articles and documents
Imaging of Enzyme Activity
-
, (2008/06/13)
This invention relates to biochemistry and magnetic resonance imaging.
Polypeptide derivatives
-
, (2008/06/13)
A biologically active peptide selected from growth factors, peptide hormones, interferons and cytokines and analogues and derivatives thereof, and bearing at least one chelating group linked to an amino group of said peptide, the chelating group being capable of complexing a detectable element and such amino group having no significant binding affinity to target receptors, are complexed with a detectable element and are useful as a pharmaceutical, e.g. a radiopharmaceutical for in vivo imaging of target tissues or for therapy.