67013-55-2

Basic information

• Product Name: Benzonitrile, 4-(dibromomethyl)-
• CAS NO: 67013-55-2
• Molecular Formula: C8H5Br2N
• Molecular Weight: 274.942
• Mol File: 67013-55-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(dibromomethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(dibromomethyl)-(67013-55-2)
• EPA Substance Registry System: Benzonitrile, 4-(dibromomethyl)-(67013-55-2)

Safety Data

• Hazardous Substances Data: 67013-55-2(Hazardous Substances Data)

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 17201-43-3 4-cyanobenzyl bromide 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 5216-36-4 4,4'-ethynediyl-di-benzonitrile 
• 29045-93-0 α,α-dibromo-p-toluic acid 
• 619-66-9 4-Carboxybenzaldehyde 
• 105-07-7 4-cyanobenzaldehyde 
• 221348-18-1 4-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl)benzonitrile 

Relevant articles and documents

One-pot synthesis of 3,5-diaryl substituted-1,2,4-oxadiazoles using gem -dibromomethylarenes

1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

MECHANISMS OF FREE-RADICAL REACTIONS. XX. REACTIVITY IN THE FREE-RADICAL HALOGENATION REACTIONS OF ARYLFLUOROALKANES

The free-radical chlorination and bromination of meta- and para-substituted benzyl fluorides and 1,1-difluoro-2-phenylethane and also the chlorination of 1-fluoro-2-arylethanes by phenylchloroiodonium chloride and the bromination of meta- and para-substituted benzyl bromides were studied by the method of competing reactions.In all cases a good correlation is observed between log krel and the Brown ?+ constants.In cases where change in the reactivity in the transition from one reaction series to another is due mainly to the polar effect of the substituent whilethe selectivity is measured in relation to the polar effect direct relationships are observed between the reactivity and the selectivity.