67104-64-7

Basic information

• Product Name: (2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE
• Synonyms: (2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE;2-BROMO-4'-METHYLBENZOPHENONE
• CAS NO: 67104-64-7
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.15
• Mol File: 67104-64-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 376.46°C at 760 mmHg
• Flash Point: 79.767°C
• Appearance: /
• Density: 1.376g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: (2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE(67104-64-7)
• EPA Substance Registry System: (2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE(67104-64-7)

Safety Data

• Hazardous Substances Data: 67104-64-7(Hazardous Substances Data)

Usage

Description

(2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE, with the molecular formula C14H11BrO, is a ketone that features a 2-bromophenyl group and a 4-methylphenyl group attached to a central methanone group. This chemical compound is recognized for its unique structure and reactivity, making it a valuable building block in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
(2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE is utilized as a key intermediate in the development of various pharmaceuticals. Its unique structure and reactivity contribute to the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Development:
(2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE also serves as a building block in the synthesis of agrochemicals, where it can be used to develop new pesticides or other agricultural products that improve crop yield and protection.
Used in Specialty Chemicals Production:
(2-BROMOPHENYL)(4-METHYLPHENYL)METHANONE is employed as a starting material in the production of dyes, pigments, and other specialty chemicals, where its distinct properties can enhance the performance and characteristics of the final products.

InChI:InChI=1/C14H11BrO/c1-10-6-8-11(9-7-10)14(16)12-4-2-3-5-13(12)15/h2-9H,1H3

Upstream product

• 108-88-3 toluene 
• 88-65-3 2-bromobenzoic-acid 
• 1002759-82-1 S-2-(tert-butylcarbamoyl)phenyl 4-methylbenzothioate 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 2042-37-7 o-cyanobromobenzene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 
• 7154-66-7 2-bromobenzoic acid chloride 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59142-66-4 (2-bromophenyl)(p-tolyl)methanol 
• 106-38-7 para-bromotoluene 

Downstream Products

• 103162-57-8 [1,1'-biphenyl]-2,2'-diylbis(p-tolylmethanone) 
• 67104-57-8 10,10-dibenzyl-3-methyl-5-phenyl-5,10-dihydro-acridarsine 
• 103162-55-6 10,10-bis(4-methylphenyl)-9-phenanthrone 
• 262439-57-6 (S)-(2-bromophenyl)-(4'-methylphenyl)methanol 
• 1186677-91-7 (E)-1-bromo-2-[1-(4-methylphenyl)-2-methoxyethenyl]benzene 
• 59142-66-4 (2-bromophenyl)(p-tolyl)methanol 
• 24218-12-0 (S)-(4-Methylphenyl)phenylmethanol 
• 15832-68-5 (S)-neobenodine 
• 1134949-07-7 1-bromo-2-[1-(4-methylphenyl)ethenyl]benzene 
• 746651-78-5 ethyl 4-(2-bromobenzoyl)benzoate 
• 886755-45-9 3-(4-ethoxycarbonylphenyl)indazole 
• 170632-41-4 1-benzyl-3-(4'-ethoxycarbonylphenyl)indazole 
• 1023896-54-9 2-(4-methylbenzoyl)benzonitrile 
• 21615-75-8 3-(4-tolyl)-isobenzofuranone 

Relevant articles and documents

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.

Palladium(II)-catalyzed Intermolecular Cascade Cyclization of Methylenecyclopropanes with Aromatic Alkynes: Construction of Spirocyclic Compounds Containing Indene and 1,2-Dihydronaphthalene Moieties

A palladium(II)-catalyzed intermolecular cascade cyclization of methylenecyclopropanes with aromatic alkynes is reported in this paper. The reaction involves a migratory insertion of alkyne, an intramolecular Heck-type reaction, and β-H elimination, providing a series of spirocyclic compounds containing indene and 1,2-dihydronaphthalene moieties in moderate to excellent yields upon heating.

Preparation method of indazole and application of indazole in medicine synthesis

The invention belongs to the field of chemicals, and relates to a preparation method of indazole and an application of the indazole in medicine synthesis. The invention discloses a preparation method of indazole and an application of the indazole in synthesizing 1H-indazole-3-carboxylic acid, lonidamine, a compound 8, a compound 9, a compound 10, axitinib, YD-3, YC-1 and similar substances thereof.