67173-18-6

Basic information

• Product Name: 3-(1-HYDROXYETHYL)BENZOPHENONE
• Synonyms: 3-(1-HYDROXYETHYL)BENZOPHENONE;[3-(1-Hydroxyethyl)phenyl]phenylMethanone;α-(3-Benzoylphenyl)ethyl Alcohol;alpha-(3-Benzoylphenyl)ethyl alcohol;Ibuprofen Impurity 26;Ibuprofen Impurity 6 (3-(1-Hydroxyethyl)benzophenone)
• CAS NO: 67173-18-6
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27046
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 67173-18-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 385.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 14.15±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 3-(1-HYDROXYETHYL)BENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-HYDROXYETHYL)BENZOPHENONE(67173-18-6)
• EPA Substance Registry System: 3-(1-HYDROXYETHYL)BENZOPHENONE(67173-18-6)

Safety Data

• Hazardous Substances Data: 67173-18-6(Hazardous Substances Data)

Usage

Description

3-(1-Hydroxyethyl)benzophenone is an organic compound that is formed as a photodegradation product of Ibuprofen (I40000) and Ketoprofen (K200800) in aqueous solutions. It is characterized by its molecular structure that includes a benzophenone core with a hydroxyethyl group attached to the third position.

Uses

Used in Environmental Monitoring:
3-(1-Hydroxyethyl)benzophenone is used as a marker compound for monitoring the photodegradation of Ibuprofen and Ketoprofen in aqueous environments. Its presence indicates the extent of degradation of these pharmaceuticals, which can be relevant for assessing water quality and the impact of pharmaceuticals on the environment.
Used in Pharmaceutical Research:
3-(1-Hydroxyethyl)benzophenone serves as a subject of study in pharmaceutical research to understand the degradation pathways and mechanisms of Ibuprofen and Ketoprofen. This knowledge can contribute to the development of more environmentally friendly pharmaceuticals and inform strategies for waste management and water treatment processes.

Upstream product

• 22071-15-4 ketoprofen 
• 2241846-02-4 1,3-dioxoisoindolin-2-yl 2-(3-benzoylphenyl)propanoate 
• 66067-43-4 3-ethylbenzophenone 
• 60695-82-1 1-(3-benzoylphenyl)-1-bromoethane 

Relevant articles and documents

Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide

Decarboxylative aminoxylation of aliphatic carboxylic acid derivatives with (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) in the presence of ruthenium photoredox catalysis is reported. The key transformation entails a highly efficient photoredox catalytic cycle using Hantzsch ester as a reductant. The ensuing alkoxyamine can be readily converted to the corresponding alcohol in one pot, representing an alternative approach to access aliphatic alcohols under photoredox conditions.

Formal intramolecular photoredox chemistry of meta-substituted benzophenones

(Chemical Equation Presented) Photolysis of 3-(hydroxymethyl)benzophenone (1) in aqueous solution (pH -4 M) conditions. Evidence suggests that the highly efficient (Φ ～ 0.6) reaction involves a unimolecular mechanism and an overall formal intramolecular photoredox process, which requires electronic communication between the 1,3-positions of the benzene ring, an unprecedented example of the photochemical meta effect. The photoredox reaction was not observed in organic solvents, where only photoreduction of the benzophenone moiety was observed.

OXIDATIVE DECARBOXYLATION OF CARBOXYLIC ACIDS BY IRON PORPHYRIN - IODOSYLBENZENE SYSTEM

An iodosylbenzene - iron tetraarylporphyrin catalyst system decarboxylated α-aryl carboxylic acids and α,α,α-trisubstituted acetic acids efficiently to give the corresponding alcohol and carbonyl derivatives.