67237-87-0

Basic information

• Product Name: 3-(4-methylphenyl)isoquinoline
• Synonyms: 3-(4-methylphenyl)isoquinoline
• CAS NO: 67237-87-0
• Molecular Weight: 219.286
• Mol File: 67237-87-0.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 3-(4-methylphenyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)isoquinoline(67237-87-0)
• EPA Substance Registry System: 3-(4-methylphenyl)isoquinoline(67237-87-0)

Safety Data

• Hazardous Substances Data: 67237-87-0(Hazardous Substances Data)

Upstream product

• 194292-30-3 1-chloro-3-p-tolyl-isoquinoline 
• 5159-41-1 2-iodobenzyl alcohol 
• 189008-33-1 2-[2-(4-methylphenyl)ethynyl]benzaldehyde 
• 85-44-9 phthalic anhydride 
• 106-38-7 para-bromotoluene 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 
• 18904-38-6 N-benzyl-2-pyridinecarboxamide 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 75159-10-3 N-(4-methylbenzylidene)-p-toluenesulfonamide 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 104-84-7 para-methylbenzylamine 
• 101207-45-8 2-(4-methylbenzyl)-1H-isoindol-1,3(2H)-dione 
• 26260-02-6 2-iodobenzaldehyde 

Relevant articles and documents

Cobalt-Mediated Decarboxylative/Desilylative C?H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues

A Co(II)-mediated decarboxylative/desilylative C?H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforw

NHC-Mediated Stetter-Aldol and Imino-Stetter-Aldol Domino Cyclization to Naphthalen-1(2 H)-ones and Isoquinolines

N-Heterocyclic carbene-catalyzed tandem Stetter-aldol reaction of phthalaldehyde and α,β-unsaturated ketimines has been developed to afford functionalized naphthalen-1(2H)-one derivatives as the formal [4+2] annulation product. Interestingly, the reaction of aldimines led to the formation of isoquinoline derivatives instead of the expected indanone derivatives as a [4+1] annulation product.

Method for synthesizing isoquinoline compound

The invention discloses a method for synthesizing an isoquinoline compound. The isoquinoline compound is shown in formula I, wherein R1 is hydrogen, a halogen atom, an alkyl, an alkoxy or an amino, and R2 is hydrogen, a halogen atom, an alkyl, an alkoxy or an amino. According to the invention, o-alkynyl aldehyde and p-hydroxybenzylamine are used as raw materials to synthesize a target product through series reactions of imidization, cyclization and oxidation elimination, the method for synthesizing the isoquinoline compound is simple and rapid, the yield of the target compound is high, and a necessary basis is provided for further researching the compound in formula I or related compounds.