67273-43-2 Usage
Structure
Benzimidazole derivative with a pyridine group attached to the benzimidazole ring
Classification
Proton pump inhibitor
Use
Treatment of conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers
Mechanism of action
Selective and irreversible inhibition of the H+/K+ ATPase enzyme system responsible for acid production in the stomach
Effect
Alleviation of symptoms associated with excessive stomach acid
Check Digit Verification of cas no
The CAS Registry Mumber 67273-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,7,2,7 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67273-43:
(7*6)+(6*7)+(5*2)+(4*7)+(3*3)+(2*4)+(1*3)=142
142 % 10 = 2
So 67273-43-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H13N3/c1-2-10-7-8-13(15-9-10)14-16-11-5-3-4-6-12(11)17-14/h3-9H,2H2,1H3,(H,16,17)
67273-43-2Relevant articles and documents
Synthesis of a group of 1H-benzimidazoles and their screening for antiinflammatory activity
Evans,Hicks,Williamson,Dawson,Meacock,Kitchen
, p. 635 - 642 (2007/10/03)
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Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
Tsukamoto,Yoshino,Kohno,Ohtaka,Kagaya,Ito
, p. 734 - 738 (2007/10/02)
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole was selected for further study. A comparison of this compound with phenylbutazone and tiaramide revealed that it possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.
