674790-29-5

Basic information

• Product Name: β-(1-benzyltetrahydroindazol-3-yl)alanine
• CAS NO: 674790-29-5
• Molecular Weight: 497.635
• Mol File: 674790-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: β-(1-benzyltetrahydroindazol-3-yl)alanine(CAS DataBase Reference)
• NIST Chemistry Reference: β-(1-benzyltetrahydroindazol-3-yl)alanine(674790-29-5)
• EPA Substance Registry System: β-(1-benzyltetrahydroindazol-3-yl)alanine(674790-29-5)

Safety Data

• Hazardous Substances Data: 674790-29-5(Hazardous Substances Data)

Upstream product

• 126-81-8 dimedone 
• 1073-62-7 N-benzylhydrazine hydrochloride 
• 674790-14-8 tert-butyl (S)-2-tert-butoxycarbonylamino-4-oxo-4-(4,4-dimethyl-2,6-dioxocyclohex-1-yl)butanoate 

Downstream Products

• 674790-35-3 2-amino-3-(1-benzyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-propionic acid 

Relevant articles and documents

Expedient synthesis of a novel class of pseudoaromatic amino acids: Tetrahydroindazol-3-yl- and tetrahydrobenzisoxazol-3-ylalanine derivatives

A concise synthesis of novel homochiral aromatic amino acid surrogates comprising a tetrahydroindazole or a benzisoxazole system was developed via the acylation of a cyclic 1,3-diketone by the side-chain carboxyl functionality of either Boc-Asp-OtBu or Boc-Glu-OtBu followed by regioselective condensation with hydrazine, N-benzylhydrazine and hydroxylamine. The tetrahydroindazole nucleus was also constructed by the condensation of Boc-Asp-OtBu with the enamine, 1-pyrrolidino-1-cyclohexene followed by acid-hydrolytic treatment and reaction with hydrazines. Further functional group transformations gave N α-Fmoc-protected derivatives as useful building blocks for solid-phase peptide assembly.