676560-85-3

Basic information

• Product Name: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt
• Synonyms: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt;(2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoroacetate;Velpatasvir Intermediate 4
• CAS NO: 676560-85-3
• Molecular Formula: C₂HF₃O₂*C₈H₁₅NO₂
• Molecular Weight: 271.24
• Mol File: 676560-85-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(676560-85-3)
• EPA Substance Registry System: (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2- trifluoro acetate salt(676560-85-3)

Safety Data

• Hazardous Substances Data: 676560-85-3(Hazardous Substances Data)

Usage

Description

(2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt is a pyrrolidine carboxylic acid ester derivative used in organic synthesis and pharmaceutical research. It is typically found in the form of a salt with trifluoroacetate, which contributes to its stability and solubility in certain chemical environments. This unique chemical structure and properties make it a promising building block in the synthesis of complex organic molecules for drug development.

Uses

Used in Pharmaceutical Research and Development:
(2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt is used as a building block in the synthesis of complex organic molecules for the development of new drugs and pharmaceuticals. Its unique chemical structure and properties make it a valuable component in the creation of innovative therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt is used as a key intermediate for the synthesis of various organic compounds. Its trifluoroacetate salt form enhances its reactivity and compatibility with other chemical reagents, facilitating the formation of desired products in organic reactions.
Used in Drug Delivery Systems:
(2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt may be employed in the development of drug delivery systems to improve the bioavailability and therapeutic efficacy of pharmaceutical agents. Its unique chemical properties can be leveraged to design targeted drug delivery systems, enhancing the delivery of therapeutic agents to specific tissues or cells.
Used in Medicinal Chemistry:
In medicinal chemistry, (2S,5S)-ethyl 5-methylpyrrolidine-2-carboxylate 2,2,2-trifluoro acetate salt is used as a versatile scaffold for the design and synthesis of novel bioactive compounds. Its unique stereochemistry and functional groups can be modified to create new molecules with potential therapeutic applications, contributing to the discovery of innovative drugs for various diseases and conditions.

Upstream product

• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 913251-58-8 (S)-2-(tert-butoxycarbonylamino)-5-oxohexanoic acid ethyl ester 
• 1448310-17-5 (S)-ethyl 5-methyl-3,4-dihydro-2H-pyrrole-2-carboxylate 2,2,2-trifluoro acetate salt 

Downstream Products

• 1448309-79-2 (2S,5S)-N-((R)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxoethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 1448309-80-5 (2S,5S)-N-((S)-1-(2-chlorophenyl)-2-(4,4-difluorocyclohexylamino)-2-oxo ethyl)-N-(3-fluorophenyl)-5-methyl-1-(pyrimidin-2-yl)pyrrolidine-2-carboxamide 
• 1335316-40-9 (2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carboxylic acid 
• 1378391-43-5 (2R,4R)-1-tert-butyl 2-(2-(9-((2S,5S)-1-((S)-2-(methoxycarbonylamino)-3-methylbutanoyl)-5-methylpyrrolidine-2-carbonyloxy)-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 4-(methoxymethyl)pyrrolidine-1,2-dicarboxylate 
• 1335315-74-6 methyl N-[(1S)-1-[(2S,5S)-2-[4-[4-[4-[2-[(2S,5S)-1-[2-(methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidin-2-yl]-1H-benzimidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate 
• 1335316-38-5 methyl N-[2-methyl-1-[(2S,5S)-2-methyl-5-[4-[4-[4-[2-[(2S,5S)-5-methylpyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-benzimidazol-2-yl]pyrrolidine-1-carbonyl]propyl]-carbamate 
• 1335316-35-2 tert-butyl (2S,5S)-2-[4-[4-[4-[2-[(2S,5S)-1-[2-(methoxycarbonylamino)-3-methyl-butanoyl]-5-methyl-pyrrolidin-2-yl]-1H-benzimidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]-5-methyl-pyrrolidine-1-carboxylate 
• 725265-95-2 4-phenylbutanoyl-5(S)-methyl-L-proline ethyl ester 
• 676560-83-1 (2S,5S)-5-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 

Relevant articles and documents

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

COMPOUNDS HAVING PROLYL OLIGOPEPTIDASE INHIBITORY ACTIVITY

The invention provides a compound of formula (I), wherein in the formula X, R1, R2 and R3 are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as a prolyl oligopeptidase inhibitor. The compounds of formula (I) can be used for the treatment of diseases or conditions where prolyl oligopeptidase inhibitors are indicated to be effective, for example for the treatment of neurodegenerative diseases, such as Alzheimer's disease and senile dementia