67661-55-6Relevant articles and documents
Active ester functionalized azobenzenes as versatile building blocks
Schultzke, Sven,Staubitz, Anne,Walther, Melanie
supporting information, (2021/07/12)
Azobenzenes are important molecular switches that can still be difficult to functionalize selectively. A high yielding Pd-catalyzed cross-coupling method under mild conditions for the introduction of NHS esters to azobenzenes and diazocines has been established. Yields were consistently high with very few exceptions. The NHS functionalized azobenzenes react with primary amines quantitatively. These amines are ubiquitous in biological systems and in material science.
Photoswitchable Antagonists for a Precise Spatiotemporal Control of β2-Adrenoceptors
Duran-Corbera, Anna,Catena, Juanlo,Otero-Vi?as, Marta,Llebaria, Amadeu,Rovira, Xavier
, p. 8458 - 8470 (2020/09/22)
β2-Adrenoceptors (β2-AR) are prototypical G-protein-coupled receptors and important pharmacological targets with relevant roles in physiological processes and diseases. Herein, we introduce Photoazolol-1-3, a series of photoswitchable azobenzene β2-AR ant
Optical Control of the GTP Affinity of K-Ras(G12C) by a Photoswitchable Inhibitor
Ge, Zhihua,Yang, Zhuojin,Liang, Jingshi,Dong, Duoling,Zhu, Mingyan
, p. 2916 - 2920 (2019/11/03)
Photocontrol of protein activity is an emerging field in biomedicine. For optical control of a mutant small GTPase K-Ras(G12C), we developed small-molecule inhibitors with photoswitchable efficacy, where one configuration binds the target protein and exer
