67736-18-9

Basic information

• Product Name: 1,3-Benzenediol, 4-(2-benzofuranyl)-
• CAS NO: 67736-18-9
• Molecular Formula: C14H10O3
• Molecular Weight: 226.232
• Mol File: 67736-18-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenediol, 4-(2-benzofuranyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenediol, 4-(2-benzofuranyl)-(67736-18-9)
• EPA Substance Registry System: 1,3-Benzenediol, 4-(2-benzofuranyl)-(67736-18-9)

Safety Data

• Hazardous Substances Data: 67736-18-9(Hazardous Substances Data)

Upstream product

• 280551-95-3 2-fluoro-1-benzofuran 
• 108-46-3 recorcinol 
• 614-75-5 2-Hydroxyphenylacetic acid 

Relevant articles and documents

Acid-mediated intermolecular C-F/C-H cross-coupling of 2-fluorobenzofurans with arenes: Synthesis of 2-arylbenzofurans

Transition-metal-free acid-promoted biaryl construction was achieved via intermolecular C-F/C-H cross-coupling. By treating 2-fluorobenzofurans with arenes in the presence of AlCl3, 2-arylbenzofurans were obtained. This protocol was successfully applied to the short-step orthogonal synthesis of a bioactive 2-arylbenzofuran natural product, which allows independent transformations of C-F and C-Br bonds. Mechanistic studies indicated that α-fluorine-stabilized carbocations, generated via the protonation of 2-fluorobenzofurans, served as key intermediates. The Friedel-Crafts-type C-C bond formation between the α-fluorocarbocations and arenes, followed by hydrogen fluoride elimination, afforded 2-arylbenzofurans. This journal is