68185-94-4

Basic information

• Product Name: Silane, trimethyl(4-methylbenzoyl)-
• CAS NO: 68185-94-4
• Molecular Formula: C11H16OSi
• Molecular Weight: 192.333
• Mol File: 68185-94-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl(4-methylbenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl(4-methylbenzoyl)-(68185-94-4)
• EPA Substance Registry System: Silane, trimethyl(4-methylbenzoyl)-(68185-94-4)

Safety Data

• Hazardous Substances Data: 68185-94-4(Hazardous Substances Data)

Upstream product

• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 75-77-4 chloro-trimethyl-silane 
• 104-87-0 4-methyl-benzaldehyde 
• 130552-03-3 Trimethyl-(2-p-tolyl-[1,3]dithian-2-yl)-silane 
• 56637-44-6 2-(4-methylphenyl)-1,3-dithiane 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 56074-62-5 2,2-bis-(4-methoxyphenyl)-1-p-tolylethanone 
• 728-87-0 4,4'-Dimethoxybenzhydrol 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 79841-56-8 (E)-(p-Tolyl)trimethylsilyl thioketone 
• 235092-45-2 p-Tolyl trimethylsilyl ketone tosylhydrazone 
• 37620-61-4 5-methyl-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one 
• 93-58-3 benzoic acid methyl ester 
• 34966-53-5 methyl 4-methylphenylglyoxylate 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 38925-77-8 4-methyl-N-(2-phenylethyl)benzamide 

Relevant articles and documents

Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions

We report the facile amide-forming ligation of acylsilanes with hydroxylamines (ASHA ligation) under aqueous conditions. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biologically active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si?O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chemistry and chemical biology.

Ruthenium-Catalyzed Brook Rearrangement Involved Domino Sequence Enabled by Acylsilane-Aldehyde Corporation

A ruthenium-catalyzed [1,2]-Brook rearrangement involved domino sequence is presented to prepare highly functionalized silyloxy indenes with atomic- and step-economy. This domino reaction is triggered by acylsilane-directed C-H activation, and the aldehyde controlled the subsequent enol cyclization/Brook Rearrangement other than β-H elimination. The protocol tolerates a broad substitution pattern, and the further synthetic elaboration of silyloxy indenes allows access to a diverse range of interesting indene and indanone derivatives.

Palladium-catalyzed carbonylative coupling reactions of aryl iodides with hexamethyldisilane (HMDS) to benzoyl silanes

A novel procedure for the palladium-catalyzed carbonylative synthesis of acyl silanes has been developed. Starting from aryl iodides and hexamethyldisilane (HMDS) various benzoyl silanes are produced in moderate to good yields.