683241-86-3

Basic information

• Product Name: 4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROBENZENAMINE
• Synonyms: 4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROBENZENAMINE;5-Amino-2-bromo-4-nitrobenzotrifluoride;4-Bromo-2-nitro-5-(trifluoromethyl)aniline;4-Bromo-2-nitro-5-trifluoromethyl-phenylamine
• CAS NO: 683241-86-3
• Molecular Formula: C₇H₄BrF₃N₂O₂
• Molecular Weight: 285.03
• Mol File: 683241-86-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 310.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.859±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -2.49±0.25(Predicted)
• CAS DataBase Reference: 4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROBENZENAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROBENZENAMINE(683241-86-3)
• EPA Substance Registry System: 4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROBENZENAMINE(683241-86-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 683241-86-3(Hazardous Substances Data)

Usage

General Description

4-Bromo-5-(trifluoromethyl)-2-nitrobenzenamine is a chemical compound with the molecular formula C7H4BrF3N2O2. It is a yellow solid that is mainly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. The presence of a bromine atom, a trifluoromethyl group, and a nitro group in its structure makes it a versatile building block for the development of new compounds. Its applications also extend to the fields of material science and organic synthesis. The compound is known to be harmful if inhaled, ingested, or in contact with the skin, and proper precautions must be taken when handling it.

Upstream product

• 402-14-2 2-nitro-5-(trifluoromethyl)aniline 
• 157554-76-2 N-[4-bromo-2-nitro-5-(trifluoromethyl)phenyl]acetamide 
• 393-36-2 4-bromo-3-(trifluoromethyl)aniline 
• 156425-51-3 N-(4-bromo-2-nitro-5-trifluoromethyl-phenyl)-2,2,2-trifluoro-acetamide 
• 41513-05-7 N-(4-bromo-3-trifluoromethylphenyl)acetamide 

Downstream Products

• 1345117-61-4 2,6-difluoro-N-(5-(6-(trifluoromethyl)benzo[c][1,2,5]thiadiazol-5-yl)pyridin-2-yl)benzamide 
• 683243-08-5 N-(4-(trifluoromethyl)benzyl)-6-(trifluoromethyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-5-ylamine 
• 157590-60-8 4-bromo-5-(trifluoromethyl)benzene-1,2-diamine 

Relevant articles and documents

NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS

This invention relates to novel compounds which are antagonists or inverse agonists at one or more of the opioid receptors, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy.

Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H- benzimidazoles

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Herein, we describe the synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2- ylpiperazin-1-yl)-1H-benzo-[d]imidazoles as novel TRPV1 antagonists. Compound 46ad was among the most potent analogues in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA).