6833-02-9Relevant articles and documents
Synthesis of N,N′-diarylalkanediamides and their antimycobacterial and antialgal activity
Kubicova, Lenka,Waisser, Karel,Kunes, Jiri,Kralova, Katarina,Odlerova, Zelmira,Slosarek, Milan,Janota, Jiri,Svoboda, Zbynek
, p. 714 - 726 (2007/10/03)
A set of N,N′-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N′-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacteri-ally active substances were found only in the series of N,N′-diarylethanediamides and N,N′-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antial-gal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.
SYNTHESIS AND REACTIONS OF N-(p-CHLOROSULPHONYLPHENYL)-SUCCINIMIDE, -GLUTARIMIDE AND -CAMPHORIMIDE
Cremlyn, Richard,Nunes, Ricardo
, p. 183 - 186 (2007/10/02)
N-Phenyl-succinimide, -glutarimide and -camphorimide mreact with chlorosulphonic acid to yield the corresponding sulphonyl chlorides.Condensation with nucleophiles afforded 25 sulphonyl derivatives, which are to be examined for biocidal properties. reacti
