68377-91-3

Basic information

• Product Name: AROTINOLOL HCL
• Synonyms: AROTINOLOL HCL;AROTINOLOL HYDROCHLORIDE;(+-)-2-(3’-tert-butylamino-2’-hydroxypropylthio)-4-(5’-carbamoyl-2’-thienyl);2-thiophenecarboxamide,5-(2-((3-((1,1-dimethylethyl)amino)-2-hydroxypropyl)thi;monohydrochloride,(+-)-o)-4-thiazolyl);s596;thiazolehcl;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, monohydrochloride
• CAS NO: 68377-91-3
• Molecular Formula: C15H22ClN3O2S3
• Molecular Weight: 408
• Product Categories: API
• Mol File: 68377-91-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 234-235.5° (dec)
• Boiling Point: 599.8 °C at 760mmHg
• Flash Point: 316.6 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 3.09E-15mmHg at 25°C
• Refractive Index: 1.646
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility: Practically insoluble in water
• Merck: 14,791
• CAS DataBase Reference: AROTINOLOL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: AROTINOLOL HCL(68377-91-3)
• EPA Substance Registry System: AROTINOLOL HCL(68377-91-3)

Safety Data

• RIDADR: UN 2811 6.1/PG III
• RTECS: XM8301000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 68377-91-3(Hazardous Substances Data)

Usage

Description

Arotinolol hydrochloride is a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

Uses

Used in Pharmaceutical Industry:
Arotinolol HCL is used as an antihypertensive agent for the treatment of hypertension. It works by blocking the action of adrenaline on β-adrenergic receptors, reducing heart rate and blood pressure, and providing relief from hypertension-related symptoms.

Originator

Sumitomo (Japan)

Therapeutic Function

Beta-adrenergic blocker

InChI:InChI=1/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20)

Upstream product

• 68257-90-9 5-(2-bromoacetyl)thiophene-2-carboxamide 
• 68257-89-6 5-acetylthiophene-2-carboxamide 
• 4101-81-9 methyl 5-acetyl-2-thiophenecarboxylate 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 52560-89-1 5-(2-mercapto-1,3-thiazol-4-yl)-2-thiophene carboxamide 
• 68377-92-4 arotinolol 
• 75-64-9 tert-butylamine 

Relevant articles and documents

Preparation method of arotinolol hydrochloride

The invention provides a preparation method of arotinolol hydrochloride, which comprises the following steps of: reacting a compound shown as a structural formula VIII with absolute methanol in the presence of concentrated sulfuric acid to obtain a compou

Preparation process for arotinolol hydrochloride with high purity

The invention discloses a preparation process for arotinolol hydrochloride with high purity. The preparation process comprises the following steps: pouring an acid-binding agent into an alcohol-watercompounded solvent, adding a compound namely 5-(2-sulfhydryl-4-thiazole)-2-thiophenecarboxamide, then adding epichlorohydrin, carrying out a reaction at a room temperature, and carrying out filteringand drying so as to obtain an intermediate III; pouring tert-butylamine into anhydrous ethanol, adding the intermediate III, carrying out a micro-reflux reaction, carrying out concentration, adding purified water, carrying out dissolving under heating, carrying out cooling, adjusting the pH value of an obtained solution to be acidic, carrying out washing with an organic solvent, adding ethanol into an aqueous layer, carrying out dissolving under heating, and carrying out cooling crystallization, and carrying out filtering so as to obtain a crude product; and pouring the crude product into an alcohol-water compounded solvent, carrying out dissolving under heating, and carrying out cooling crystallization, filtering and drying so as to obtain the arotinolol hydrochloride with high purity. The preparation process provided by the invention can effectively remove impurities from arotinolol hydrochloride, can reach a purity of 99.95% or above, and has simple operation and high yield.