6844-18-4

Basic information

• Product Name: 1-Naphthalenemethanol, a-(4-methoxyphenyl)-
• CAS NO: 6844-18-4
• Molecular Formula: C18H16O2
• Molecular Weight: 264.324
• Mol File: 6844-18-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-Naphthalenemethanol, a-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Naphthalenemethanol, a-(4-methoxyphenyl)-(6844-18-4)
• EPA Substance Registry System: 1-Naphthalenemethanol, a-(4-methoxyphenyl)-(6844-18-4)

Safety Data

• Hazardous Substances Data: 6844-18-4(Hazardous Substances Data)

Usage

Appearance

White crystalline solid

Common uses

Synthesis of pharmaceuticals and organic compounds, fragrance ingredient in perfumes, starting material for the production of other chemicals, building block for the synthesis of pharmaceuticals and other organic compounds, production of various drugs, reagent in organic chemistry reactions

Safety

Relatively safe when handled and used according to proper precautions and guidelines

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 66-77-3 1-naphthaldehyde 
• 100-66-3 methoxybenzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 86-55-5 1-naphthalenecarboxylic acid 
• 18052-80-7 1-naphthyltrimethylsilane 
• 123-11-5 4-methoxy-benzaldehyde 
• 5720-07-0 4-methoxyphenylboronic acid 
• 39070-92-3 (4-methoxyphenyl)(naphthalen-1-yl)methanone 
• 703-55-9 1-naphthylmagnesiumbromide 

Downstream Products

• 32891-88-6 (4-methoxyphenyl)(naphth-1-yl)methane 
• 677761-68-1 (4-methoxyphenyl)(2-methyl-4-hydroxyphenyl)(naphth-1-yl)methane 
• 586949-84-0 (4-methoxyphenyl)(3-methyl-4-hydroxyphenyl)(naphth-1-yl)methane 
• 1456695-48-9 C₂₄H₂₀OS 
• 1456695-49-0 C₂₄H₂₁NO 
• 1456695-59-2 C₂₄H₂₁NO 
• 1456695-50-3 C₂₅H₂₃NO 
• 1456695-60-5 C₂₅H₂₃NO 
• 1456695-51-4 C₂₆H₂₅NO 
• 873991-01-6 (4-methoxy-phenyl)-[1]naphthyl-(toluene-4-sulfonyl)-methane 

Relevant articles and documents

Nickel-Catalyzed Addition of Aryl Bromides to Aldehydes to Form Hindered Secondary Alcohols

Transition-metal-catalyzed addition of aryl halides across carbonyls remains poorly developed, especially for aliphatic aldehydes and hindered substrate combinations. We report here that simple nickel complexes of bipyridine and PyBox can catalyze the addition of aryl halides to both aromatic and aliphatic aldehydes using zinc metal as the reducing agent. This convenient approach tolerates acidic functional groups that are not compatible with Grignard reactions, yet sterically hindered substrates still couple in high yield (33 examples, 70% average yield). Mechanistic studies show that an arylnickel, and not an arylzinc, adds efficiently to cyclohexanecarboxaldehyde, but only in the presence of a Lewis acid co-catalyst (ZnBr2).

Synthetic approach towards trisubstituted methanes and a chiral tertiary α-hydroxyaldehyde, a possible intermediate for tetrasubstituted methanes

A series of trisubstituted methanes containing aryl and heteroaryl rings, as well as a sulfur spacer between the central methano-carbon and benzene ring, is reported. In an approach towards asymmetric tetrasubstituted methane with high enantioselectivity,

Use of cheaper metal than Rh, CHCl3-free Pd catalyst, in 1,2-addition of aromatic aldehydes with arylboronic acids

Pd(OAc)2-(±)-tol-BINAP-catalyzed arylation reaction of aromatic aldehydes with arylboronic acids in the absence of CHCl3 is described.