68835-89-2

Basic information

• Product Name: DI-TERT-AMYL DICARBONATE
• Synonyms: PYROCARBONIC ACID DI-TERT-AMYL ESTER;(AMOC)2O;DI-AMOC;DI-TERT-PENTYL DICARBONATE;DI-TERT-AMYL DICARBONATE;DI-TERT-AMYL PYROCARBONATE;Pyrocarbonicacidamylester;bis-tert-pentyl dicarbonate
• CAS NO: 68835-89-2
• Molecular Formula: C₁₂H₂₂O₅
• Molecular Weight: 246.3
• EINECS: 272-436-1
• Mol File: 68835-89-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 70 °C0.05 mm Hg(lit.)
• Flash Point: 220 °F
• Appearance: /
• Density: 1.006 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: n20/D 1.422(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DI-TERT-AMYL DICARBONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DI-TERT-AMYL DICARBONATE(68835-89-2)
• EPA Substance Registry System: DI-TERT-AMYL DICARBONATE(68835-89-2)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• F: 9
• Hazardous Substances Data: 68835-89-2(Hazardous Substances Data)

Usage

General Description

Di-tert-amyl dicarbonate, also known as di-tert-amyl carbonate, is a chemical compound used in the pharmaceutical industry as a protecting group for amines in organic synthesis. It is a clear, colorless liquid with a fruity odor and is insoluble in water. Di-tert-amyl dicarbonate is commonly used in the production of pharmaceuticals to temporarily mask the amine functional groups in drug molecules, facilitating the synthesis of complex organic compounds. It has also been studied for its potential application in carbon capture technologies. However, di-tert-amyl dicarbonate can be hazardous if not handled properly and should be used in a controlled environment with appropriate safety measures.

InChI:InChI=1/C12H22O5/c1-7-11(3,4)16-9(13)15-10(14)17-12(5,6)8-2/h7-8H2,1-6H3

Upstream product

• 124-38-9 carbon dioxide 

Downstream Products

• 1206968-10-6 1,1-Dimethylpropyl 4-[2-(4-methanesulfonylphenoxymethyl)-pyridin-5-yl]piperidine-1-carboxylate 
• 114779-60-1 N-Amoc-DL-α-methyl tryptophanyl-L-phenylalaninepiperidineamide 
• 114779-52-1 N-Amoc-DL-α-methyl tryptophanyl-2-(3,4-dichlorophenyl)ethylamide 
• 114779-39-4 N-Amoc-DL-α-methyl tryptophanyl-L-(1-hydroxymethyl-2-phenyl)ethylamide 
• 114779-50-9 N-Amoc-DL-α-methyl tryptophanyl-2-(4-methoxyphenyl)ethylamide 
• 114779-51-0 N-Amoc-DL-α-methyl tryptophanyl-2-(4-chlorophenyl)ethylamide 
• 129397-53-1 N-Amoc-DL-α-methyl tryptophanyl-2-(4-methylphenyl)ethylamide 
• 129397-52-0 1,1-dimethylpropyl (+/-)-<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<(phenylethyl)amino>ethyl>carbamate 
• 1053629-62-1 C₄₈H₆₁Cl₆NO₁₈ 
• 82882-70-0 N^α-tert-amyloxycarbonyl-N^im-tritylhistidine 
• 114779-81-6 N-Amoc-DL-α-methyl tryptophan 

Relevant articles and documents

Pyrocarbonic acid diesters and the preparation and use thereof

The invention relates to the preparation of pyrocarbonic acid diesters by an improved process and to the novel pyrocarbonic acid diesters prepared according to said process as well as to the use thereof.The core of the invention is a process for the preparation of a pyrocarbonic acid diester of formula (I) wherein R1 and R1′ are each independently of the other branched or straight-chain C1-C24alkyl, C3-C24alkenyl, C3-C24alkynyl, C4-C12cycloalkyl, C4-C12cycloalkenyl or C7-C24aralkyl, each of which is unsubstituted or substituted by one or more than one substituent which is inert under the reaction conditions,by reacting at least one ester carbonate of formula (II) ?with 40-50 mol % of a sulfochloride of formula (IV) ?in the presence of 0.8-5 mol % of a catalyst of formula (V) and with minor amounts of a heterocyclic aromatic amine in a nonpolar inert solvent,in which process the amount of heterocyclic aromatic amine is 1-3 mol % and the reaction is carried out in the temperature range from ?10° C. to ±25° C., all molar amounts being based on 100 mol % of ester carbonate of formula (II).