6908-75-4

Basic information

• Product Name: Pyrrolidine, 1-(2-phenylethyl)-
• CAS NO: 6908-75-4
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Mol File: 6908-75-4.mol
• Article Data: 36

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(2-phenylethyl)-(6908-75-4)
• EPA Substance Registry System: Pyrrolidine, 1-(2-phenylethyl)-(6908-75-4)

Safety Data

• Hazardous Substances Data: 6908-75-4(Hazardous Substances Data)

Upstream product

• 1016-50-8 N-phenethylsuccinimide 
• 73160-83-5 1-(1-methylsulfanyl-2-phenyl-ethylidene)-pyrrolidinium; iodide 
• 123-91-1 1,4-dioxane 
• 110-63-4 Butane-1,4-diol 
• 64-04-0 phenethylamine 
• 123-75-1 pyrrolidine 
• 60-12-8 2-phenylethanol 
• 6908-73-2 (E)-1-styrylpyrrolidine 
• 100-52-7 benzaldehyde 
• 122-78-1 phenylacetaldehyde 
• 17376-04-4 2-phenethyl iodide 
• 100-42-5 styrene 
• 609-36-9 rac-Pro-OH 
• 55628-82-5 1-(Phenylacetyl)imidazole 

Downstream Products

• 65486-36-4 1-phenethyl-pyrrolidine-2-thione 
• 10220-22-1 1-(4-nitro-phenyl)-pyrrolidine 
• 127236-89-9 1-Benzotriazol-1-ylmethyl-1-phenethyl-pyrrolidinium; iodide 

Relevant articles and documents

Insights into Rare-Earth Metal Complex-Mediated Hydroamination

Since the precise understanding of the underlying mechanism is important for the rational design of catalysts, much attention has been paid for hydroamination reactions catalyzed by organolanthanides during the past three decades. Distinct mechanisms were

Two-Step Protocol for Iodotrimethylsilane-Mediated Deoxy-Functionalization of Alcohols

We have developed a two-step protocol for iodotrimethylsilane-mediated deoxy-functionalization of primary and secondary alcohols to afford products containing a C?N, C?S, or C?O bond. In the first step the alcohol undergoes iodination with iodotrimethylsilane, and in the second, the iodine atom is replaced by a N, S, or O nucleophile. Compared with traditional Mitsunobu reaction, non-acidic pre-nucleophiles can be used, and the reaction proceeds with retention of configuration. This operationally simple, highly efficient protocol can be used for some natural products and small-molecule drugs containing hydroxy-group.

Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali-Metal Amides under Air

A straightforward alkali-metal-mediated hydroamination of styrenes using biorenewable 2-methyltetrahydrofuran as a solvent is reported. Refuting the conventional wisdom of the incompatibility of organolithium reagents with air and moisture, shown here is that the presence of moisture is key in favoring formation of the target phenethylamines over competing olefin polymerization products. The method is also compatible with sodium amides, with the latter showing excellent promise as highly efficient catalysts under inert atmosphere conditions.