6920-38-3

Basic information

• Product Name: LUTEOLIN-4'-O-GLUCOSIDE
• Synonyms: 3',4',5,7-TETRAHYDROXYFLAVONE-4'-GLUCOSIDE;LUTEOLIN-4'-GLUCOSIDE;LUTEOLIN-4'-O-GLUCOSIDE;2-(4-β-D-Glucopyranosyloxy-3-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;2-[3-Hydroxy-4-(β-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one;3',5,7-Trihydroxy-4'-(β-D-glucopyranosyloxy)flavone;4'-β-D-O-Glucopyranosylluteolin
• CAS NO: 6920-38-3
• Molecular Formula: C₂₁H₂₀O₁₁
• Molecular Weight: 448.38
• Product Categories: Tetra-substituted Flavones
• Mol File: 6920-38-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 210°C (dec.)
• Boiling Point: 814.5°C at 760 mmHg
• Flash Point: 288.5°C
• Appearance: /
• Density: 1.713g/cm³
• Vapor Pressure: 4.74E-28mmHg at 25°C
• Refractive Index: 1.74
• PKA: 6.49±0.40(Predicted)
• CAS DataBase Reference: LUTEOLIN-4'-O-GLUCOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: LUTEOLIN-4'-O-GLUCOSIDE(6920-38-3)
• EPA Substance Registry System: LUTEOLIN-4'-O-GLUCOSIDE(6920-38-3)

Safety Data

• Hazardous Substances Data: 6920-38-3(Hazardous Substances Data)

Usage

General Description

LUTEOLIN-4'-O-GLUCOSIDE is a flavonoid that is commonly found in various fruits and vegetables, including celery, green pepper, parsley, and chamomile. It is known for its potential health benefits, including antioxidant, anti-inflammatory, and anticancer properties. LUTEOLIN-4'-O-GLUCOSIDE has been studied for its ability to protect against oxidative stress and inflammation, as well as its potential for inhibiting the growth of cancer cells. Additionally, it has been investigated for its potential role in promoting cardiovascular health and reducing the risk of chronic diseases. Research on LUTEOLIN-4'-O-GLUCOSIDE is ongoing, and it may hold promise for developing new treatments and preventive strategies for various health conditions.

InChI:InChI=1/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)31-13-2-1-8(3-10(13)24)14-6-12(26)17-11(25)4-9(23)5-15(17)30-14/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1

Upstream product

• 70404-47-6 luteolin 4'-O-β-D-glucopyranoside 7-O-β-D-glucopyranoside 
• 133-89-1 UDP-glucose 
• 491-70-3 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on 

Relevant articles and documents

Biological synthesis of isorhamnetin 3-O-glucoside using engineered glucosyltransferase

The gene for one of the glycosyltransferases from Populus deltoids, PGT-3, was cloned and was expressed as a glutathione S-transferase fusion protein in Escherichia coli. Various flavonoids were used as potential substrates of the purified recombinant PGT-3. Flavones having two adjacent hydroxyl groups were served as substrate. The regioselectivity of PGT-3 depends on the hydroxyl groups of the substrate. Flavones having two adjacent hydroxyl groups in the B ring were glucosylated at the 4′-hydroxyl group. However, PGT-3 transferred a glucose group to the 3-hydroxyl group of isorhamnetin. Molecular modeling and docking and site-directed mutagenesis were carried out to engineer a PGT-3 having a specificity for isorhamnetin but not for quercetin. Glu82Leu turned out to display this activity. Using the Glu82Leu mutant and a quercetin 3′- O-methyltransferase, isorhamnetin 3- O-glucoside was synthesized.