6928-85-4 Usage
Description
1-Amino-4-methylpiperazine, a derivative of piperazine, is a clear colorless to light yellow liquid. It is widely used as an intermediate in the synthesis of various pharmaceutical agents, including Rifampicin, an antibiotic used to treat several types of bacterial infections such as tuberculosis, leprosy, and Legionnaire's disease.
Uses
1. Used in Pharmaceutical Synthesis:
1-Amino-4-methylpiperazine is used as an intermediate for the synthesis of various pharmaceutical agents, including Rifampicin, an antibiotic effective against tuberculosis, leprosy, and Legionnaire's disease.
2. Used in Chemical Synthesis:
1-Amino-4-methylpiperazine is used as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm) and in the synthesis of various compounds, such as:
Pyrazolo-pyrazine and pyridine derivatives
2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
N-(4-Fluorobenzylidene)-4-methylpiperazin-1-amine
4-Methyl-N-(3,4,5-trimethoxybenzylidene)piperazin-1-amine
N-(3,4-Dichlorobenzylidene)-4-methylpiperazin-1-amine
N-(4-(Diethylamino)benzylidene)-4-methylpiperazin-1-amine
N-(2,5-Dimethoxybenzylidene)-4-methylpiperazin-1-amine
4-Methyl-N-((5-nitrofuran-2-yl)methylene)piperazin-1-amine
These applications highlight the versatility of 1-Amino-4-methylpiperazine in different industries, particularly in the pharmaceutical and chemical synthesis sectors.
Preparation
1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine.
Flammability and Explosibility
Notclassified
Check Digit Verification of cas no
The CAS Registry Mumber 6928-85-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,2 and 8 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6928-85:
(6*6)+(5*9)+(4*2)+(3*8)+(2*8)+(1*5)=134
134 % 10 = 4
So 6928-85-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H13N3/c1-7-2-4-8(6)5-3-7/h2-6H2,1H3
6928-85-4Relevant articles and documents
Cyclization of N,N-bis(2-chloroethyl)methylamine in aqueous hydrazine
Kushakova,Kuznetsov,Chernobroviy,Garabadgiu
, p. 960 - 961 (2004)
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Method for synthesizing 1-amino-4-methylpiperazine through catalytic hydrogenation
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Paragraph 0044-0046; 0068, (2020/07/28)
The invention relates to a method for synthesizing 1-amino-4-methylpiperazine through catalytic hydrogenation. The invention discloses the green synthesis method for synthesizing 1-amino-4-methylpiperazine by hydrogenating 1-methyl-4-nitrosopiperazine in a water and organic mixed solvent system under the catalysis of an iron oxide and ferrous oxide supported palladium catalyst, wherein the methodcomprises the steps: adding 1-methyl-4-nitrosopiperazine into a paramagnetic Pd/Fe3O4-FeO catalyst, carrying out a hydrogenation reaction in a three-phase system of water, an organic solvent and the catalyst at a certain temperature, and finally, carrying out reduced pressure distillation separation to obtain the target product 1-amino-4-methylpiperazine. The 1-amino-4-methylpiperazine is preparedby innovatively using a catalytic hydrogenation method in a three-phase system, and compared with a traditional synthesis method, the method is more environmentally friendly and safer, and the cost is saved.
Selective reduction of N-nitroso aza-aliphatic cyclic compounds to the corresponding N-amino products using zinc dust in CO2–H2O medium
Yang, Weiqing,Lu, Xiang,Zhou, Tingting,Cao, Yongjing,Zhang, Yuanyuan,Ma, Menglin
, p. 780 - 783 (2018/10/20)
[Figure not available: see fulltext.] A new method for reduction of N-nitroso aza-aliphatic cyclic compounds employing zinc in pressurized CO2–H2O medium has been developed. H2O and NH4Cl were used as hydrogen donors, and reduction was performed under environmentally benign conditions. The presented approach allowed to obtain the respective N-amino products selectively and in excellent yields (up to 97%).