69383-68-2

Basic information

• Product Name: 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE
• Synonyms: 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE;4-Chloride-6-nitro-1,3-xylin
• CAS NO: 69383-68-2
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 69383-68-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 270.8 °C at 760 mmHg
• Flash Point: 117.5 °C
• Appearance: /
• Density: 1.273 g/cm³
• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE(69383-68-2)
• EPA Substance Registry System: 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE(69383-68-2)

Safety Data

• Hazardous Substances Data: 69383-68-2(Hazardous Substances Data)

Usage

General Description

1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE, also known as nitrochloro-xylene, is a chemical compound with the molecular formula C8H8ClNO2. It is a yellowish-brown solid with a molecular weight of 189.60 g/mol. 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE is primarily used as an intermediate for the synthesis of various pharmaceuticals, dyes, and agrochemicals. It is also used in organic synthesis and as a reagent in chemical reactions. 1-CHLORO-2,4-DIMETHYL-5-NITRO-BENZENE is a potentially hazardous chemical and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system, and may be harmful if ingested or inhaled in large quantities. Therefore, proper safety precautions should be taken when working with this compound.

InChI:InChI=1/C8H8ClNO2/c1-5-3-6(2)8(10(11)12)4-7(5)9/h3-4H,1-2H3

Upstream product

• 89-87-2 2,4-dimethylnitrobenzene 
• 2124-47-2 5-nitro-2,4-dimethylaniline 
• 89-69-0 2,4,5-Trichloronitrobenzene 
• 1481-68-1 5-chloro-2,4-difluoronitrobenzene 
• 616-72-8 4,6-dinitro-m-xylene 
• 7647-01-0 hydrogenchloride 
• 95-66-9 2,4-dimethylchlorobenzene 

Downstream Products

• 69383-61-5 5-chloro-2,4-dimethylaniline 
• 162100-82-5 2-chloro-5-methyl-4-nitro-benzoic acid 
• 342045-61-8 4-chloro-6-nitro-isophthalic acid 
• 69383-63-7 4-Amino-6-chlor-1.3-dimethyl-benzol-2-sulfonsaeure 

Relevant articles and documents

ISOINDOLINONE COMPOUNDS

Disclosed herein is a compound or pharmaceutically acceptable salts or stereoisomers thereof of of formula I wherein X1 is linear or branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C1-6 alkyl C6-10 aryl, C1-6 alkyl 5-10 membered heteroaryl, wherein X1 is unsubstituted or substituted with one or more of halogen, linear or branched C1-6 alkyl, linear or branched C1-6 heteroalkyl, CF3, CHF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C1-6 alkylamino, -CN, -N(H)C(O)-C1- 6alkyl, -OC(O)-C1-6alkyl, -OC(O)-C1-4alkylamino, -C(O)O-C1-6alkyl, -COOH, - CHO, -C1-6alkylC(O)OH, -C1-6alkylC(O)O-C1-6alkyl, NH2, C1-6 alkoxy or C1-6 alkylhydroxy; X2 is hydrogen, C6-10 aryl, 5-10 membered heteroaryl, -O-(5-10 membered heteroaryl), 4-8 membered heterocycloalkyl, C1-4 alkyl 4-8 membered heterocycloalkyl, -O-(4-8 membered heterocycloalkyl), -O-C1-4 alkyl-(4-8 membered heterocycloalkyl), -OC(O)-C1-4alkyl-4-8 membered heterocycloalkyl or C6 aryloxy, wherein X2 is unsubstituted or substituted with one or more of linear or branched C1-6 alkyl, NH2, NMe2 or 5-6 membered heterocycloalkyl; n is 0, 1 or 2.

A new route to prepare 6-chloro-5-(2-chloroethyl)oxindole

6-Chloro-5-(2-chloroethyl)oxindole, a key intermediate in the manufacturing of the antipsychotic drug, ziprasidone, has been synthesized by a new route. The salient features of the synthesis are (1) bis-dialkylation of 2,4-difluoro-5-chloronitrobenzene with sodium diethyl malonate, (2) decarboxylative hydrolysis to obtain the oxindole derivative, and (3) reduction and chlorination of acetic ester side chain.