6953-60-2 Usage
Description
S-Acetylmercaptosuccinic anhydride is an amine reactive reagent that contains a sulfhydryl group. It undergoes a ring-opening reaction when attacked by an amine nucleophile, forming an amine linkage. During this reaction, a free carboxylate group is formed, which renders the molecule negatively charged. This charge reversal affects the activity of the molecule towards proteins and its conformation.
Uses
Used in Pharmaceutical Industry:
S-Acetylmercaptosuccinic anhydride is used as a pharmaceutical agent for its potential therapeutic effects. The negatively charged molecule can interact with proteins and modulate their activity, making it a promising candidate for the development of drugs targeting various diseases.
Used in Chemical Research:
S-Acetylmercaptosuccinic anhydride is used as a research tool in chemical studies. Its unique properties, such as the ring-opening reaction and charge reversal, make it an interesting subject for investigating the mechanisms of amine reactivity and the effects of charge on molecular interactions.
Used in Biochemical Applications:
S-Acetylmercaptosuccinic anhydride is used in biochemical applications for its ability to modify proteins and other biomolecules. The introduction of a negatively charged group can alter the conformation and activity of these molecules, providing insights into their structure and function.
Used in Drug Delivery Systems:
S-Acetylmercaptosuccinic anhydride can be used in the development of drug delivery systems. Its ability to form amine linkages and introduce a negatively charged group can be utilized to improve the targeting, stability, and release of therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 6953-60-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,5 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 6953-60:
(6*6)+(5*9)+(4*5)+(3*3)+(2*6)+(1*0)=122
122 % 10 = 2
So 6953-60-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H6O4S/c1-3(7)11-4-2-5(8)10-6(4)9/h4H,2H2,1H3/t4-/m0/s1
6953-60-2Relevant articles and documents
Regioselective ring opening of thiomalic acid anhydrides by carbon nucleophiles. Synthesis and X-ray structure elucidation of novel thiophenone derivatives
Kikionis, Stefanos,McKee, Vickie,Markopoulos, John,Igglessi-Markopoulou, Olga
experimental part, p. 3711 - 3716 (2009/09/05)
Novel and promising thiophenone derivatives were synthesised by regioselective ring opening of activated thiomalic acid anhydrides, with a variety of active methylene nucleophiles via a C-acylation/cyclisation process involving an S-C bond formation. This
