69825-50-9

Basic information

• Product Name: Glycine, N-(2-methoxyphenyl)-, ethyl ester
• CAS NO: 69825-50-9
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Mol File: 69825-50-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Glycine, N-(2-methoxyphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-(2-methoxyphenyl)-, ethyl ester(69825-50-9)
• EPA Substance Registry System: Glycine, N-(2-methoxyphenyl)-, ethyl ester(69825-50-9)

Safety Data

• Hazardous Substances Data: 69825-50-9(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 105-36-2 ethyl bromoacetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 924-44-7 glyoxylic acid ethyl ester 
• 578-57-4 2-bromoanisole 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1391490-70-2 ethyl 8-methoxy-4-phenylquinoline-2-carboxylate 
• 112255-65-9 2-((2-methoxyphenyl)amino)acetohydrazide 
• 94800-23-4 (2-methoxyphenyl)glycine 
• 86323-86-6 [(3-Mercapto-propionyl)-(2-methoxy-phenyl)-amino]-acetic acid 

Relevant articles and documents

Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ

Cyclic azodicarbonyl derivatives, particularly 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD), commonly serve as arenophile, dienophile, enophile and electrophile. Perplexed by its instability in aqueous environment, there are few studies focused on the transient intermediate produced by hydrolysis of PTAD to achieve synthetic significance. Herein, we describe a “photo-click” method that involves nitrile imine (NI) from diarylsydnone to capture the diazenecarbonyl-phenyl-carbamic acid (DACPA) generated by water-promoted ring-opening of PTAD. DFT calculation reveal that H-bonding interactions between PTAD and water are vital to form DACPA which exhibited an umpolung effect during ligation by nature bond orbit (NBO) analysis. The ultra-fast ligation resulted in carbamoyl formazans, as a unique Z?E photo-switchable linker on target molecules, including peptide and drugs, with excellent anti-fatigue performance. This strategy is showcased to construct highly functionalized carbamoyl formazans in situ for photo-pharmacology and material studies, which also expands the chemistry of PTAD in aqueous media.

Synthesis and biological potentials of some new 1,3,4-oxadiazole analogues

In continuation of our research to explore new antiproliferative agents, we report herein the synthesis and antiproliferative activity of two new series of N-(substituted phenyl)-5-aryl-1,3,4-oxadiazol-2-amine (4a–j) and N-{[5-aryl-1,3,4-oxadiazol-2-yl]me

Preparation method of nerve regeneration amide medicine

The invention relates to a preparation method of a nerve regeneration amide medicine. The method is characterized in that the nerve regeneration amide medicine is prepared from o-methoxyaniline and ethyl glyoxalate through a four-step reaction, and the method concretely comprises the following steps: carrying out a reductive amination reaction on the raw materials comprising o-methoxyaniline and ethyl glyoxalate to obtain an intermediate I, reacting the intermediate with p-toluensulfonyl chloride to obtain an intermediate II, hydrolyzing the intermediate II to obtain an intermediate III, and reacting the intermediate III with 3-amino-4-methoxypyridine to obtain the final product. The preparation method has the advantages of low irritation in the synthesis reaction process, convenience in production and high molecule yield, and is a 2-[(2-methoxyphenyl)-(4-methylbenzenesulfonyl)]amino-N-(4-methoxypyridyl)-3-acetamide production method suitable for industrial production.