699-02-5

Basic information

• Product Name: 2-(4-METHYLPHENYL)ETHANOL
• Synonyms: 2-(4-METHYLPHENYL)ETHANOL;2-(P-TOLYL)ETHANOL;4-METHYLPHENETHYL ALCOHOL;P-METHYLPHENETHYL ALCOHOL;2-(p-Methylphenyl)ethanol;4-methyl-benzeneethano;4-Methylbenzeneethanol;4-methyl-Benzeneethanol
• CAS NO: 699-02-5
• Molecular Formula: C₉H₁₂O
• Molecular Weight: 136.19
• EINECS: 211-824-7
• Product Categories: Alcohols;C9 to C30;Oxygen Compounds;Building Blocks;C9 to C10;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 699-02-5.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 244-245 °C(lit.)
• Flash Point: 225 °F
• Appearance: Clear colorless to faintly yellow liquid
• Density: 0.978 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.92±0.10(Predicted)
• CAS DataBase Reference: 2-(4-METHYLPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENYL)ETHANOL(699-02-5)
• EPA Substance Registry System: 2-(4-METHYLPHENYL)ETHANOL(699-02-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 699-02-5(Hazardous Substances Data)

Usage

Description

2-(4-METHYLPHENYL)ETHANOL, also known as 4-Methylphenethyl alcohol, is a clear colorless to faintly yellow liquid with distinct chemical properties. It is an organic compound that has found various applications across different industries due to its unique characteristics.

Uses

Used in Pharmaceutical and Chemical Research:
2-(4-METHYLPHENYL)ETHANOL is used as a reagent for the determination of adducts of 1,2and 1,4-benzoquinone with cysteine residues of hemoglobin and albumin. This application is particularly important in the study of the effects of quinones on proteins and their potential implications in various diseases.
Used in the Flavor and Fragrance Industry:
2-(4-METHYLPHENYL)ETHANOL is used as a flavoring agent for its distinctive aromatic properties. It contributes to the creation of various scents and flavors in the production of perfumes, cosmetics, and the food and beverage industry.
Used in the Chemical Synthesis Industry:
2-(4-METHYLPHENYL)ETHANOL serves as a key intermediate in the synthesis of various chemicals and pharmaceuticals. Its unique structure allows it to be a valuable building block in the development of new compounds with potential applications in different fields.

InChI:InChI=1/C9H12O/c1-8-2-4-9(5-3-8)6-7-10/h2-5,10H,6-7H2,1H3

Upstream product

• 106-44-5 p-cresol 
• 64-17-5 ethanol 
• 1431794-52-3 potassium trifluoro(4-methylphenethyl)borate 
• 13107-39-6 2-(4-methylphenyl)oxirane 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 106-45-6 para-thiocresol 
• 107-07-3 2-chloro-ethanol 
• 622-47-9 4-tolylacetic acid 
• 771-51-7 indole-3-acetonitrile 
• 100-39-0 benzyl bromide 
• 1953-54-4 indol-5-ol 
• 670-95-1 4-Phenylimidazole 
• 122-00-9 para-methylacetophenone 
• 2947-61-7 (4-methylphenyl)acetonitrile 

Downstream Products

• 104-09-6 4-methylphenylacetaldehyde 
• 22381-54-0 2-(p-tolylsulfonyl)ethanol 
• 1092381-54-8 (E)-4,4′-(prop-1-ene-1,3-diyl)bis(methylbenzene) 
• 73475-98-6 1,3-bis(4-methylphenyl)propane 
• 104-87-0 4-methyl-benzaldehyde 
• 163164-47-4 4-mono(2-hydroxyethyl)benzaldehyde 
• 69776-92-7 (±)-4-methylphenyloxazolidin-2-one 
• 4371-50-0 para-cymen-9-ol 

Relevant articles and documents

Borane evolution and its application to organic synthesis using the phase-vanishing method

Although borane is a useful reagent, it is difficult to handle. In this study, borane was generated in situ from NaBH4 or nBu4NBH4 with several oxidants using a phase-vanishing (PV) method. The borane generated was directly reacted with alkenes, affording the desired alcohols in good yields after oxidation with H2O2 under basic conditions. The selective reduction of carboxylic acids with the evolved borane was examined. The organoboranes generated by the PV method successfully underwent Suzuki–Miyaura coupling. Using this PV system, reactions with borane can be carried out easily and safely in a common test tube.

Regiodivergent Hydroborative Ring Opening of Epoxides via Selective C-O Bond Activation

A magnesium-catalyzed regiodivergent C-O bond cleavage protocol is presented. Readily available magnesium catalysts achieve the selective hydroboration of a wide range of epoxides and oxetanes yielding secondary and tertiary alcohols in excellent yields and regioselectivities. Experimental mechanistic investigations and DFT calculations provide insight into the unexpected regiodivergence and explain the different mechanisms of the C-O bond activation and product formation.

Diaminodiphosphine tetradentate ligand and ruthenium complex thereof, and preparation methods and applications of ligand and complex

The invention discloses a diaminodiphosphine tetradentate ligand and a ruthenium complex thereof, and preparation methods and applications of the ligand and the complex, and provides a ruthenium complex represented by a formula I, wherein L is a diaminodiphosphine tetradentate ligand represented by a formula II, and X and Y are respectively and independently chlorine ion, bromine ion, iodine ion,hydrogen negative ion or BH4. According to the present invention, the ruthenium complex exhibits excellent catalytic activity in the catalytic hydrogenation reactions of ester compounds, has high yield and high chemical selectivity, is compatible with conjugated and non-conjugated carbon-carbon double bond, carbon-carbon triple bond, epoxy, halogen, carbonyl and other functional groups, and hasgreat application prospects.