70-45-1

Basic information

• Product Name: L-LEUCINE-UL-14C
• Synonyms: LEUCINE, L-[14C(U)]-;L-LEUCINE, [U-14C];L-LEUCINE-UL-14C;L-[U-14C]LEUCINE;L-Leucine-UL-14C hydrochloride
• CAS NO: 70-45-1
• Molecular Formula: C6H13NO2
• Molecular Weight: 143.28
• Mol File: 70-45-1.mol
• Article Data: 155

Chemical Properties

• Appearance: /aqueous ethanol solution
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-LEUCINE-UL-14C(CAS DataBase Reference)
• NIST Chemistry Reference: L-LEUCINE-UL-14C(70-45-1)
• EPA Substance Registry System: L-LEUCINE-UL-14C(70-45-1)

Safety Data

• Hazard Codes: Xi,R
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2910 7
• WGK Germany: 3
• Hazardous Substances Data: 70-45-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

Upstream product

• 873963-42-9 2-acetylamino-2-cyano-4-methyl-valeric acid ethyl ester 
• 151962-48-0 acetylamino-isobutyl-malonic acid diethyl ester 
• 816-66-0 4-methyl-2-oxopentanoic acid 
• 19506-89-9 N-phthaloyl-DL-leucine 
• 6707-69-3 N-(o-carboxybenzoyl)-L-leucine 
• 7732-18-5 water 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 121-44-8 triethylamine 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 10303-64-7 2-hydroxy-4-methylpentanoic acid 
• 24292-07-7 D-α-Hydrazino-isocapronsaeure 
• 80089-22-1 L-leucine (phenylmethyl)ester 
• 89384-51-0 (R)-N-benzylleucine 
• 13079-20-4 2-Amino-4-methyl-pentanoic acid amide 

Downstream Products

• 60889-69-2 N-(N-benzoyl-glycyl)-leucine 
• 57744-46-4 Ac-ΔPhe-(S)-Leu-OH 
• 503621-76-9 N-formimidoyl-L-leucine 
• 102129-41-9 N-[(2,4,5-trichloro-phenoxy)-acetyl]-DL-leucine 
• 108272-66-8 N-(4-chloro-benzyloxycarbonyl)-leucine 
• 117910-69-7 N-(4-nitro-benzoyl)-D-leucine 
• 65952-92-3 4-methyl-2-(4-nitrobenzamido)-pentanoic acid 
• 100950-73-0 N-[2-(2,4-dinitro-phenylhydrazono)-propionyl]-leucine 

Relevant articles and documents

Screening for Amidases: Isolation and Characterization of a Novel D-Amidase from Variovorax paradoxus

Using racemic tert-leucine amide as sole nitrogen source in minimal medium, 162 strains were isolated by enrichment techniques and shown to contain amidase activity. Among these isolates three D-amidase producers were found and identified as Variovorax pa

Argicyclamides A-C Unveil Enzymatic Basis for Guanidine Bis-prenylation

Guanidine prenylation is an outstanding modification in alkaloid and peptide biosynthesis, but its enzymatic basis has remained elusive. We report the isolation of argicyclamides, a new class of cyanobactins with unique mono- and bis-prenylations on guanidine moieties, from Microcystis aeruginosa NIES-88. The genetic basis of argicyclamide biosynthesis was established by the heterologous expression and in vitro characterization of biosynthetic enzymes including AgcF, a new guanidine prenyltransferase. This study provides important insight into the biosynthesis of prenylated guanidines and offers a new toolkit for peptide modification.

Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics

Malaria remains a worldwide threat, afflicting over 200 million people each year. The emergence of drug resistance against existing therapeutics threatens to destabilize global efforts aimed at controlling Plasmodium spp. parasites, which is expected to leave vast portions of humanity unprotected against the disease. To address this need, systematic testing of a fungal natural product extract library assembled through the University of Oklahoma Citizen Science Soil Collection Program has generated an initial set of bioactive extracts that exhibit potent antiplasmodial activity (EC50 25 μM, selectivity index > 250). The unique chemodiversity afforded by these fungal isolates serves to unlock new opportunities for translating peptaibols into a bioactive scaffold worthy of further development.