700-45-8 Usage
Description
5-Fluoro-1,2,3,4-tetrahydronaphthalene is an organic compound with the molecular formula C10H9F. It is a fluorinated derivative of tetrahydronaphthalene, which is a saturated hydrocarbon with a six-membered ring and a five-membered ring fused together. The presence of the fluorine atom in the molecule provides unique chemical and biological properties, making it a valuable intermediate in the synthesis of various pharmaceuticals and chemical compounds.
Uses
Used in Pharmaceutical Industry:
5-Fluoro-1,2,3,4-tetrahydronaphthalene is used as a key intermediate in the synthesis of sulfonamides, which are a class of antimicrobial agents. These sulfonamides act as inhibitors of the chemokine receptor CCR8, playing a crucial role in the treatment of eosinophil and Th2-mediated diseases.
Used in Treatment of Eosinophil and Th2-Mediated Diseases:
5-Fluoro-1,2,3,4-tetrahydronaphthalene is used as a building block for the development of drugs targeting eosinophil and Th2-mediated diseases such as asthma, allergic dermatitis, and rheumatoid arthritis. By inhibiting the chemokine receptor CCR8, these drugs can help regulate the immune response and alleviate the symptoms associated with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 700-45-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 700-45:
(5*7)+(4*0)+(3*0)+(2*4)+(1*5)=48
48 % 10 = 8
So 700-45-8 is a valid CAS Registry Number.
700-45-8Relevant articles and documents
COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
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Paragraph 0328; 0416, (2021/08/27)
The present disclosure is directed to adenine analogs, methods of making adenine analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis,
ARYL SULFONAMIDES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTOR ACTIVITY
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, (2008/06/13)
The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, X, Z, R2, X., Ar, n, R3 and R4 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and acc
CCR8 INHIBITORS
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Page 178-179, (2008/06/13)
Disclosed is an inhibitor of CCR8 that is represented by Structural Formula (I). Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier or diluent and a CCR8 inhibitor represented by Structural Formula (I). Also disclosed is a method of treating inflammatory disorders in a subject by administering a CCR8 inhibitor to the subject.
