701-47-3

Basic information

• Product Name: alpha-ethyl-p-fluorobenzyl alcohol
• Synonyms: 1-(4-FLUOROPHENYL)PROPANOL-1;1-(4-Fluorophenyl)-1-propanol;α-Ethyl-4-fluorobenzenemethanol;alpha-Ethyl-4-fluorobenzyl alcohol;alpha-Ethyl-4-fluorobenzyl alcohol, 1-(4-Fluorophenyl)-1-hydroxypropane
• CAS NO: 701-47-3
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814
• EINECS: 211-856-1
• Mol File: 701-47-3.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 218.6°Cat760mmHg
• Flash Point: 106°C
• Appearance: /
• Density: 1.091g/cm³
• Vapor Pressure: 0.0724mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: alpha-ethyl-p-fluorobenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-ethyl-p-fluorobenzyl alcohol(701-47-3)
• EPA Substance Registry System: alpha-ethyl-p-fluorobenzyl alcohol(701-47-3)

Safety Data

• Hazardous Substances Data: 701-47-3(Hazardous Substances Data)

Usage

General Description

Alpha-Ethyl-p-fluorobenzyl alcohol is an organic compound with the chemical formula C9H11FO. It is a colorless liquid with a sweet, floral odor, commonly used in the synthesis of pharmaceuticals and as a fragrance ingredient in perfumes and personal care products. alpha-Ethyl-p-fluorobenzyl alcohol is also known for its potential as a chloresterol-lowering agent and has been studied for its mild sedative and anticonvulsant properties. It can be prepared through the reaction of p-fluorobenzaldehyde with ethylmagnesium bromide, followed by a reduction with lithium aluminum hydride. Alpha-Ethyl-p-fluorobenzyl alcohol is considered to be relatively stable under normal conditions, but should be handled with caution due to its potential irritant and toxic effects if ingested or inhaled.

InChI:InChI=1/C9H11FO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6,9,11H,2H2,1H3

Upstream product

• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 925-90-6 ethylmagnesium bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 557-20-0 diethylzinc 
• 75175-77-8 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 123-38-6 propionaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 74-96-4 ethyl bromide 
• 5724-03-8 1-(4-fluorophenyl)allyl alcohol 
• 124980-95-6 (E)-3-(4-fluorophenyl)-2-propen-1-ol 
• 24393-50-8 ethyl 4-fluorocinnamate 
• 31736-68-2 2-(4'-fluorophenyl)oxetane 

Downstream Products

• 1345412-59-0 (R)-1-(4-fluorophenyl)propyl diphenylacetate 
• 166371-89-7 (R)-1-(4-fluorophenyl)-1-propanol 
• 166371-89-7 (S)-1-(4-fluorophenyl)propanol 
• 1372174-51-0 methyl 4-((4-chloro-N-(1-(4-fluorophenyl)propyl)phenylsulfonamido)methyl)benzoate 
• 889-26-9 1-(4-phenoxyphenyl)propan-1-one 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 787-68-8 Bernsteinsaeure-mono-<1-(4-fluor-phenyl)-propylester> 
• 699-01-4 1-fluoro-4-(prop-1-en-1-yl)benzene 
• 56004-96-7 4-fluorophenylpropyl bromide 

Relevant articles and documents

Homoleptic cobalt(II) phenoxyimine complexes for hydrosilylation of aldehydes and ketones without base activation of cobalt(II)

Air-stable, easy to prepare, homoleptic cobalt(II) complexes bearing pendant-modified phenoxyimine ligands were synthesized and determined. The complexes exhibited high catalytic performance for reducing aldehydes and ketones via catalytic hydrosilylation, where a hydrosilane and a catalytic amount of the cobalt(II) complex were added under base-free conditions. The reaction proceeded even in the presence of excess water, and excellent functional-group tolerance was observed. Subsequent hydrolysis gave the alcohol in high yields. Moreover, H2O had a critical role in activation of the Co(II) catalyst with hydrosilane. Several additional results also indicated that the cobalt(II) center acts as an active catalyst in the hydrosilylation of aldehydes and ketones.

Regiodivergent Hydroborative Ring Opening of Epoxides via Selective C-O Bond Activation

A magnesium-catalyzed regiodivergent C-O bond cleavage protocol is presented. Readily available magnesium catalysts achieve the selective hydroboration of a wide range of epoxides and oxetanes yielding secondary and tertiary alcohols in excellent yields and regioselectivities. Experimental mechanistic investigations and DFT calculations provide insight into the unexpected regiodivergence and explain the different mechanisms of the C-O bond activation and product formation.

COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Described herein are compounds that act as CYP46A1 inhibitors, compositions comprising these compounds, and methods of their use into treating neurodegenerative diseases and the like, or a pharmaceutically active salt thereof. The present invention relates to compounds represented by the formula wherein each symbol is as defined in the specification, or a pharmaceutically active salt thereof.